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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
fatty acid synthase	ENSG00000169710	FASN	chr17:82078338-82098332:-	Tchem	756.406
nerve growth factor	ENSG00000134259	NGF	chr1:115285918-115338236:-	Tchem	1198.4
mesothelin	ENSG00000102854	MSLN	chr16:643262-768865:+	Tbio	349.788
CD274 molecule	ENSG00000120217	CD274	chr9:5450503-5470566:+	Tclin	912.9
CEA cell adhesion molecule 6	ENSG00000086548	CEACAM6	chr19:41750977-41772208:+	Tbio	303.337
ubiquitin C-terminal hydrolase L1	ENSG00000154277	UCHL1	chr4:41256413-41268455:+	Tchem	994.444
selectin P	ENSG00000174175	SELP	chr1:169588849-169630193:-	Tchem	3027.59
tumor protein p73	ENSG00000078900	TP73	chr1:3652520-3736201:+	Tbio	804.913
plasminogen activator, urokinase	ENSG00000122861	PLAU	chr10:73909177-73917497:+	Tchem	2077.29
Wnt family member 2	ENSG00000105989	WNT2	chr7:117276631-117323289:-	Tbio	276.228
cholinergic receptor nicotinic alpha 5 subunit	ENSG00000169684	CHRNA5	chr15:78565520-78595269:+	Tbio	147.562
COPI coat complex subunit alpha	ENSG00000122218	COPA	chr1:160289273-160343400:-	Tbio	126.013
bromodomain containing 4	ENSG00000141867	BRD4	chr19:15235519-15332545:-	Tchem	236.696
matrix metallopeptidase 14	ENSG00000157227	MMP14	chr14:22836557-22849027:+	Tchem	978.641
SET and MYND domain containing 3	ENSG00000185420	SMYD3	chr1:245749342-246507312:-	Tchem	55.1791
renin	ENSG00000143839	REN	chr1:204154819-204166322:-	Tclin	17376.3
PR/SET domain 10	ENSG00000170325	PRDM10	chr11:129899706-130002835:-	Tbio	3.33333
interleukin 33	ENSG00000137033	IL33	chr9:6215786-6257983:+	Tbio	513.135
CD36 molecule	ENSG00000135218	CD36	chr7:80369575-80679277:+	Tbio	1253.02
CD69 molecule	ENSG00000110848	CD69	chr12:9752486-9760901:-	Tbio	723.862

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