PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
G protein-coupled receptor 20ENSG00000204882GPR20chr8:141356500-141367267:-Tdark2.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 3ENSG00000126091ST3GAL3chr1:43705824-43931165:+Tbio37.7718
ATPase secretory pathway Ca2+ transporting 1ENSG00000017260ATP2C1chr3:130850595-131016712:+Tbio276.709
ATPase secretory pathway Ca2+ transporting 2ENSG00000064270ATP2C2chr16:84368527-84464187:+Tbio15.7594
protein kinase cAMP-dependent type I regulatory subunit betaENSG00000188191PRKAR1Bchr7:549197-727650:-Tbio6
LY6/PLAUR domain containing 5ENSG00000159871LYPD5chr19:43795929-43827206:-Tdark5.97549
kelch repeat and BTB domain containing 8ENSG00000163376KBTBD8chr3:66998307-67011210:+Tbio1.31667
erbb2 interacting proteinENSG00000112851ERBB2IPchr5:65926475-66082549:+Tbio70.6171
aarF domain containing kinase 5ENSG00000173137ADCK5chr8:144373101-144393242:+Tdark0
SET domain containing 3, actin histidine methyltransferaseENSG00000183576SETD3chr14:99397746-99480889:-Tdark1.33333
suppressor of variegation 3-9 homolog 2ENSG00000152455SUV39H2chr10:14878820-14904315:+Tbio15.196
solute carrier family 25 member 42ENSG00000181035SLC25A42chr19:19063999-19112888:+Tbio2.77335
neuropeptide S receptor 1ENSG00000187258NPSR1chr7:34658239-34878332:+Tchem113.533
dual specificity phosphatase 18ENSG00000167065DUSP18chr22:30652051-30667890:-Tbio7.2
cysteinyl leukotriene receptor 2ENSG00000152207CYSLTR2chr13:48653711-48711226:+Tchem76.2766
mucin 5AC, oligomeric mucus/gel-formingENSG00000215182MUC5ACchr11:1157953-1201138:+Tbio119.818
solute carrier family 35 member F1ENSG00000196376SLC35F1chr6:117907526-118317676:+Tdark0.688034
solute carrier family 37 member 3ENSG00000157800SLC37A3chr7:140293693-140404433:-Tdark1.44405
PHD finger protein 3ENSG00000118482PHF3chr6:63635820-63779336:+Tbio9.34167
thioredoxin 2ENSG00000100348TXN2chr22:36467036-36482030:-Tbio69.7301

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