PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ubiquitin specific peptidase 4ENSG00000114316USP4chr3:49277831-49340712:-Tbio49.5282
store-operated calcium entry associated regulatory factorENSG00000133872SARAFchr8:30063012-30083208:-Tbio7.31527
aminoacyl tRNA synthetase complex interacting multifunctional protein 1ENSG00000164022AIMP1chr4:106315544-106349226:+Tbio184.082
butyrophilin like 9ENSG00000165810BTNL9chr5:181040225-181061523:+Tdark2.30238
EPH receptor A5ENSG00000145242EPHA5chr4:65319563-65670495:-Tchem30.5414
solute carrier family 9 member A7ENSG00000065923SLC9A7chrX:46599252-46759172:-Tbio10.2107
titinENSG00000155657TTNchr2:178525989-178830802:-Tbio1015.49
NADPH oxidase 5ENSG00000255346NOX5chr15:68930525-69062743:+Tbio80.8192
phospholipase A2 group IIIENSG00000100078PLA2G3chr22:31134809-31140607:-Tbio12.6997
WNK lysine deficient protein kinase 2ENSG00000165238WNK2chr9:93184916-93320572:+Tbio20.0398
potassium two pore domain channel subfamily K member 1ENSG00000135750KCNK1chr1:233614004-233672512:+Tbio46.7503
growth hormone secretagogue receptorENSG00000121853GHSRchr3:172445133-172448456:-Tclin454.197
platelet factor 4 variant 1ENSG00000109272PF4V1chr4:73853189-73854155:+Tbio16.1288
epiphycanENSG00000083782EPYCchr12:90963679-91005026:-Tbio9.86667
adenylate cyclase 9ENSG00000162104ADCY9chr16:3953387-4116185:-Tbio37.5052
galanin like peptideENSG00000197487GALPchr19:56176020-56185775:+Tbio316.541
leucyl and cystinyl aminopeptidaseENSG00000113441LNPEPchr5:96935394-97037515:+Tchem430.061
cathepsin WENSG00000172543CTSWchr11:65879809-65883741:+Tbio19.8333
solute carrier family 10 member 1ENSG00000100652SLC10A1chr14:69775417-69797289:-Tchem257.439
adrenoceptor alpha 2CENSG00000184160ADRA2Cchr4:3766348-3768526:+Tclin118.396

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