PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
atypical chemokine receptor 2ENSG00000144648ACKR2chr3:42804752-42887974:+Tbio51.3903
carboxypeptidase B1ENSG00000153002CPB1chr3:148791102-148860187:+Tchem187.239
endoplasmic reticulum oxidoreductase 1 alphaENSG00000197930ERO1Lchr14:52639916-52695900:-Tbio54.9485
kelch like family member 35ENSG00000149243KLHL35chr11:75422394-75430629:-Tdark1.69444
potassium two pore domain channel subfamily K member 7ENSG00000173338KCNK7chr11:65592855-65595996:-Tdark2.03803
WNK lysine deficient protein kinase 4ENSG00000126562WNK4chr17:42780678-42796936:+Tbio100.06
prostaglandin reductase 2ENSG00000140043PTGR2chr14:73851844-73886827:+Tbio7.45327
ectonucleotide pyrophosphatase/phosphodiesterase family member 5ENSG00000112796ENPP5chr6:46159187-46170971:-Tdark1.39444
solute carrier family 13 member 2ENSG00000007216SLC13A2chr17:28473293-28497781:+Tbio49.1921
calcium/calmodulin dependent protein kinase II betaENSG00000058404CAMK2Bchr7:44217150-44334577:-Tchem51.2425
H4 clustered histone 8ENSG00000158406HIST1H4Hchr6:26285113-26285509:-0
retinol binding protein 7ENSG00000162444RBP7chr1:9997206-10016020:+Tbio4.55833
protein arginine methyltransferase 7ENSG00000132600PRMT7chr16:68310974-68358563:+Tbio16.2151
MAX dimerization protein MLXENSG00000108788MLXchr17:42567068-42573239:+Tchem30.5873
alpha-L-fucosidase 2ENSG00000001036FUCA2chr6:143494811-143511690:-Tchem10.4954
steroid 5 alpha-reductase 3ENSG00000128039SRD5A3chr4:55346109-55373096:+Tbio18.9944
twinfilin actin binding protein 2ENSG00000247596TWF2chr3:52228610-52239260:-Tbio6.95
tubulin alpha like 3ENSG00000178462TUBAL3chr10:5393098-5404830:-Tdark0.555556
proprotein convertase subtilisin/kexin type 1 inhibitorENSG00000102109PCSK1NchrX:48831094-48835633:-Tbio23.9345
cytochrome b5 reductase 3ENSG00000100243CYB5R3chr22:42617840-42649568:-Tbio136.78

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