PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ubiquitin specific peptidase 21ENSG00000143258USP21chr1:161159450-161165723:+Tbio38.7095
solute carrier family 15 member 4ENSG00000139370SLC15A4chr12:128793191-128823983:-Tbio17.5051
retinol dehydrogenase 12ENSG00000139988RDH12chr14:67701886-67734452:+Tbio39.6533
UDP glucuronosyltransferase family 2 member B11ENSG00000213759UGT2B11chr4:69004618-69214731:-Tbio5.65317
ribosomal protein S6 kinase like 1ENSG00000198208RPS6KL1chr14:74903954-74923396:-Tdark0.066667
nephronectinENSG00000168743NPNTchr4:105894775-106004027:+Tbio26.4964
kelch like family member 17ENSG00000187961KLHL17chr1:960587-965715:+Tdark1.33333
mitogen-activated protein kinase kinase kinase kinase 2ENSG00000168067MAP4K2chr11:64784914-64803241:-Tchem7.39167
nuclear receptor subfamily 1 group H member 2ENSG00000131408NR1H2chr19:50329653-50382982:+Tchem125.468
antizyme inhibitor 1ENSG00000155096AZIN1chr8:102826357-102893864:-Tbio18.4929
ectonucleotide pyrophosphatase/phosphodiesterase 7ENSG00000182156ENPP7chr17:79730919-79742222:+Tbio17.3429
toll like receptor 9ENSG00000239732TLR9chr3:52221080-52226163:-Tclin1152.06
methyl-CpG binding domain protein 5ENSG00000204406MBD5chr2:148021011-148516971:+Tbio57.38
aldehyde dehydrogenase 9 family member A1ENSG00000143149ALDH9A1chr1:165662216-165698863:-Tbio15.9308
PR/SET domain 6ENSG00000061455PRDM6chr5:123089121-123194266:+Tbio3.52841
heme binding protein 1ENSG00000013583HEBP1chr12:12974864-13000273:-Tbio252.191
DnaJ heat shock protein family (Hsp40) member A1ENSG00000086061DNAJA1chr9:33025211-33039907:+Tchem49.9129
unc-51 like kinase 4ENSG00000168038ULK4chr3:41246599-41962430:-Tbio4.74995
phosphodiesterase 1AENSG00000115252PDE1Achr2:182140036-182523192:-Tclin23.2701
arachidonate 12-lipoxygenase, 12R typeENSG00000179477ALOX12Bchr17:8072636-8087703:-Tbio33.1906

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