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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
protocadherin beta 10	ENSG00000120324	PCDHB10	chr5:141187319-141195642:+	Tdark	0
solute carrier family 47 member 2	ENSG00000180638	SLC47A2	chr17:19678288-19718979:-	Tchem	32.6696
mitochondrial intermediate peptidase	ENSG00000027001	MIPEP	chr13:23730189-23889419:-	Tbio	20.2208
hyaluronan and proteoglycan link protein 3	ENSG00000140511	HAPLN3	chr15:88877288-88895626:-	Tdark	2.63333
RANBP2-type and C3HC4-type zinc finger containing 1	ENSG00000125826	RBCK1	chr20:407498-430966:+	Tbio	31.8611
G protein-coupled receptor 173	ENSG00000184194	GPR173	chrX:53049091-53080615:+	Tdark	2.14841
solute carrier family 26 member 1	ENSG00000145217	SLC26A1	chr4:979073-993440:-	Tbio	12.4754
angiopoietin like 2	ENSG00000136859	ANGPTL2	chr9:127087332-127122883:-	Tbio	48.9176
cortistatin	ENSG00000241563	CORT	chr1:10449719-10451902:+	Tbio	323.406
solute carrier family 44 member 3	ENSG00000143036	SLC44A3	chr1:94820342-94895246:+	Tdark	5.03571
Rh blood group CcEe antigens	ENSG00000188672	RHCE	chr1:25362249-25430192:-	Tbio	198.402
tyrosine kinase non receptor 1	ENSG00000174292	TNK1	chr17:7380534-7389774:+	Tchem	8.18228
phosphodiesterase 1B	ENSG00000123360	PDE1B	chr12:54549350-54579239:+	Tclin	16.2388
inositol polyphosphate-5-phosphatase A	ENSG00000068383	INPP5A	chr10:132537820-132783480:+	Tbio	16.1958
muscle associated receptor tyrosine kinase	ENSG00000030304	MUSK	chr9:110668771-110801579:+	Tchem	231.176
mitogen-activated protein kinase kinase kinase 14	ENSG00000006062	MAP3K14	chr17:45263121-45317040:-	Tchem	127.964
sialic acid binding Ig like lectin 11	ENSG00000161640	SIGLEC11	chr19:49948985-49961172:-	Tbio	10.5179
V-set immunoregulatory receptor	ENSG00000107738	C10orf54	chr10:71747559-71773498:-	Tbio	88.8614
thrombospondin type 1 domain containing 1	ENSG00000136114	THSD1	chr13:52377167-52406494:-	Tbio	3.46667
interleukin 21	ENSG00000138684	IL21	chr4:122612628-122621069:-	Tbio	531.072

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