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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
serine/threonine kinase 17a	ENSG00000164543	STK17A	chr7:43582758-43626786:+	Tchem	10.4018
opsin 1, short wave sensitive	ENSG00000128617	OPN1SW	chr7:128772491-128775790:-	Tbio	154.58
potassium inwardly rectifying channel subfamily J member 12	ENSG00000184185	KCNJ12	chr17:21376197-21419872:+	Tbio	62.8317
protein kinase N2	ENSG00000065243	PKN2	chr1:88684222-88836255:+	Tchem	40.7603
solute carrier family 25 member 32	ENSG00000164933	SLC25A32	chr8:103398635-103415189:-	Tbio	20.5159
calcium voltage-gated channel auxiliary subunit beta 4	ENSG00000182389	CACNB4	chr2:151832776-152099079:-	Tbio	17.9326
solute carrier family 38 member 9	ENSG00000177058	SLC38A9	chr5:55625845-55773194:-	Tbio	9.15
CDC like kinase 1	ENSG00000013441	CLK1	chr2:200853009-200864744:-	Tchem	61.5223
sirtuin 6	ENSG00000077463	SIRT6	chr19:4174109-4182604:-	Tbio	130.035
serine protease 27	ENSG00000172382	PRSS27	chr16:2712418-2720551:-	Tbio	28.9417
potassium inwardly rectifying channel subfamily J member 3	ENSG00000162989	KCNJ3	chr2:154698299-154858352:+	Tbio	114.151
solute carrier family 2 member 12	ENSG00000146411	SLC2A12	chr6:133988697-134052636:-	Tbio	19.037
MAPK activated protein kinase 3	ENSG00000114738	MAPKAPK3	chr3:50611520-50649297:+	Tbio	44.4436
clock circadian regulator	ENSG00000134852	CLOCK	chr4:55427903-55547138:-	Tbio	427.026
mucolipin 1	ENSG00000090674	MCOLN1	chr19:7522626-7534009:+	Tbio	184.638
major histocompatibility complex, class II, DQ alpha 2	ENSG00000237541	HLA-DQA2	chr6:32741342-32747215:+	Tbio	37.2563
monooxygenase DBH like 1	ENSG00000079931	MOXD1	chr6:132296055-132401545:-	Tbio	85.1
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	ENSG00000071073	MGAT4A	chr2:98619106-98731126:-	Tbio	13.7
G protein-coupled receptor class C group 5 member C	ENSG00000170412	GPRC5C	chr17:74424851-74451653:+	Tdark	3.1
calcium/calmodulin dependent serine protein kinase	ENSG00000147044	CASK	chrX:41514934-41923463:-	Tchem	112.975

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