PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
phospholipase A2 group IIFENSG00000158786PLA2G2Fchr1:20139326-20150386:+Tchem3.03535
phospholipase C delta 4ENSG00000115556PLCD4chr2:218607765-218637184:+Tbio12.5012
torsin family 2 member AENSG00000160404TOR2Achr9:127731524-127735317:-Tbio12.2833
chloride channel accessory 4ENSG00000016602CLCA4chr1:86547078-86580754:+Tbio9.93655
solute carrier family 28 member 1ENSG00000156222SLC28A1chr15:84884654-84945796:+Tbio81.6988
cholinergic receptor nicotinic beta 1 subunitENSG00000170175CHRNB1chr17:7445061-7457707:+Tclin24.8482
serine peptidase inhibitor Kazal type 13ENSG00000214510SPINK13chr5:148268180-148286254:+Tdark2.15476
interleukin 12BENSG00000113302IL12Bchr5:159314783-159330887:-Tclin391.552
cathepsin FENSG00000174080CTSFchr11:66563463-66568841:-Tchem27.1873
ubiquitin C-terminal hydrolase L5ENSG00000116750UCHL5chr1:193012250-193060080:-Tbio37.569
leukocyte immunoglobulin like receptor A1ENSG00000104974LILRA1chr19:54573879-54602090:+Tdark4.33333
pancreatic lipaseENSG00000175535PNLIPchr10:116545931-116567855:+Tclin336.767
PDZ domain containing 2ENSG00000133401PDZD2chr5:31639410-32110931:+Tbio26.6861
histone deacetylase 9ENSG00000048052HDAC9chr7:18086949-19002416:+Tclin558.949
solute carrier family 8 member A2ENSG00000118160SLC8A2chr19:47428017-47472168:-Tbio24.7286
tubulin beta 6 class VENSG00000176014TUBB6chr18:12307669-12344320:+Tclin4.99401
gamma-aminobutyric acid type A receptor subunit beta2ENSG00000145864GABRB2chr5:161288429-161549044:-Tclin39.1244
tryptophan hydroxylase 1ENSG00000129167TPH1chr11:18017564-18042426:-Tclin190.041
potassium two pore domain channel subfamily K member 12ENSG00000184261KCNK12chr2:47516581-47570939:-Tbio6.54664
microtubule associated serine/threonine kinase 2ENSG00000086015MAST2chr1:45786987-46036124:+Tbio20.0247

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