PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
glutathione S-transferase zeta 1ENSG00000100577GSTZ1chr14:77320884-77331597:+Tbio95.9171
glutathione S-transferase alpha 4ENSG00000170899GSTA4chr6:52977948-52995378:-Tbio79.9352
chloride voltage-gated channel 5ENSG00000171365CLCN5chrX:49922615-50099235:+Tbio190.315
ubiquitin specific peptidase 15ENSG00000135655USP15chr12:62260338-62417431:+Tbio23.6831
C-C motif chemokine receptor 8ENSG00000179934CCR8chr3:39329706-39333511:+Tchem81.9575
fyn related Src family tyrosine kinaseENSG00000111816FRKchr6:115931149-116060758:-Tchem72.2536
chloride voltage-gated channel 6ENSG00000011021CLCN6chr1:11806096-11843144:+Tbio17.6632
solute carrier family 6 member 11ENSG00000132164SLC6A11chr3:10816200-10940733:+Tbio19.1965
SUMO specific peptidase 1ENSG00000079387SENP1chr12:48042898-48106308:-Tbio73.5469
dual specificity phosphatase 12ENSG00000081721DUSP12chr1:161749758-161757238:+Tbio16.91
potassium voltage-gated channel subfamily Q member 5ENSG00000185760KCNQ5chr6:72621792-73198851:+Tclin30.8343
leucyl-tRNA synthetase 2, mitochondrialENSG00000011376LARS2chr3:45388506-45549421:+Tbio24.9468
carbohydrate sulfotransferase 9ENSG00000154080CHST9chr18:26906481-27185317:-Tbio3.66786
amine oxidase copper containing 2ENSG00000131480AOC2chr17:42844600-42850707:+Tchem144.342
hydroxyacid oxidase 2ENSG00000116882HAO2chr1:119368779-119394130:+Tchem65.0333
ANTXR cell adhesion molecule 1ENSG00000169604ANTXR1chr2:69013178-69249327:+Tbio52.2085
chemerin chemokine-like receptor 1ENSG00000174600CMKLR1chr12:108288044-108339341:-Tbio48.6422
ADAM metallopeptidase domain 22ENSG00000008277ADAM22chr7:87934143-88202889:+Tbio30.3702
neutral cholesterol ester hydrolase 1ENSG00000144959NCEH1chr3:172630249-172711218:-Tchem17.5238
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFENSG00000154358OBSCNchr1:228208130-228378876:+Tbio17.3417

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