PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
thioredoxin related transmembrane protein 4ENSG00000125827TMX4chr20:7977348-8019829:-Tdark3.15
G protein-coupled receptor kinase 4ENSG00000125388GRK4chr4:2963608-3040747:+Tchem76.9877
laminin subunit gamma 3ENSG00000050555LAMC3chr9:131009082-131094473:+Tbio6.71948
pyruvate dehydrogenase kinase 2ENSG00000005882PDK2chr17:50094737-50112152:+Tchem59.359
calcium/calmodulin dependent protein kinase kinase 1ENSG00000004660CAMKK1chr17:3860315-3894891:-Tchem24.3012
gamma-butyrobetaine hydroxylase 1ENSG00000129151BBOX1chr11:27040725-27127809:+Tchem48.8492
phosphatidylinositol-4-phosphate 5-kinase type 1 gammaENSG00000186111PIP5K1Cchr19:3630183-3700479:-Tchem13.8143
fin bud initiation factor homologENSG00000176971FIBINchr11:26994184-26996121:+Tdark1.40476
neuropeptides B and W receptor 1ENSG00000183729NPBWR1chr8:52938431-52941117:+Tchem19.1357
dopamine receptor D1ENSG00000184845DRD1chr5:175440039-175444208:-Tclin541.099
C-X-C motif chemokine ligand 17ENSG00000189377CXCL17chr19:42428288-42443048:-Tbio15.755
TNF superfamily member 8ENSG00000106952TNFSF8chr9:114893343-114930595:-Tbio47.5415
sulfotransferase family 1B member 1ENSG00000173597SULT1B1chr4:69721162-69787961:-Tbio17.4556
phosphorylase kinase catalytic subunit gamma 1ENSG00000164776PHKG1chr7:56080283-56092996:-Tchem5.78883
poly(ADP-ribose) polymerase family member 3ENSG00000041880PARP3chr3:51942345-51948867:+Tclin20.9968
corticotropin releasing hormoneENSG00000147571CRHchr8:66176382-66178725:-Tbio4955.22
vomeronasal 1 receptor 1ENSG00000178201VN1R1chr19:57454790-57457142:-Tbio7.7
calcium voltage-gated channel auxiliary subunit alpha2delta 1ENSG00000153956CACNA2D1chr7:81946444-82443798:-Tclin18.7024
ADAM metallopeptidase with thrombospondin type 1 motif 6ENSG00000049192ADAMTS6chr5:65148736-65481920:-Tdark3.79243
peptidylprolyl isomerase BENSG00000166794PPIBchr15:64155812-64163205:-Tchem100.645

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