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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
surfactant associated 2	ENSG00000196260	SFTA2	chr6:30931353-30932175:-	Tdark	31.7622
leucine rich transmembrane and O-methyltransferase domain containing	ENSG00000184154	LRTOMT	chr11:72080331-72110782:+	Tbio	12.663
arylsulfatase F	ENSG00000062096	ARSF	chrX:3041471-3112726:+	Tbio	97.4833
lysine demethylase 3B	ENSG00000120733	KDM3B	chr5:138352596-138437028:+	Tbio	8.34564
major histocompatibility complex, class II, DP alpha 1	ENSG00000231389	HLA-DPA1	chr6:33064569-33080775:-	Tbio	133.75
alpha-1-B glycoprotein	ENSG00000121410	A1BG	chr19:58345178-58353499:-	Tbio	330.365
growth differentiation factor 9	ENSG00000164404	GDF9	chr5:132861181-132866884:-	Tbio	139.279
N-ribosyldihydronicotinamide:quinone reductase 2	ENSG00000124588	NQO2	chr6:2987987-3028869:+	Tchem	122.886
G protein-coupled receptor 34	ENSG00000171659	GPR34	chrX:41688973-41697277:+	Tbio	15.469
somatostatin receptor 3	ENSG00000278195	SSTR3	chr22:37204238-37212322:-	Tclin	62.306
cytochrome P450 family 4 subfamily F member 22	ENSG00000171954	CYP4F22	chr19:15508493-15552317:+	Tbio	39.8802
monoglyceride lipase	ENSG00000074416	MGLL	chr3:127689062-127823250:-	Tchem	191.654
polyamine oxidase	ENSG00000148832	PAOX	chr10:133379234-133391694:+	Tchem	26.2167
potassium two pore domain channel subfamily K member 13	ENSG00000152315	KCNK13	chr14:90061765-90185857:+	Tbio	7.01667
FAT atypical cadherin 3	ENSG00000165323	FAT3	chr11:92352096-92896470:+	Tbio	9.49826
phosphodiesterase 1C	ENSG00000154678	PDE1C	chr7:31751179-32299329:-	Tclin	21.3875
CD180 molecule	ENSG00000134061	CD180	chr5:67179613-67196799:-	Tbio	29.9753
interleukin 18 receptor accessory protein	ENSG00000115607	IL18RAP	chr2:102418689-102452565:+	Tbio	35.6078
2'-5'-oligoadenylate synthetase 1	ENSG00000089127	OAS1	chr12:112906777-112933222:+	Tbio	89.3008
mitogen-activated protein kinase 4	ENSG00000141639	MAPK4	chr18:50560078-50731824:+	Tbio	15.5657

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