PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
FKBP prolyl isomerase 1BENSG00000119782FKBP1Bchr2:24049701-24063681:+Tchem84.7626
dual specificity phosphatase 19ENSG00000162999DUSP19chr2:183078559-183100005:+Tdark4.61667
tubulointerstitial nephritis antigenENSG00000137251TINAGchr6:54307859-54390152:+Tbio18.5
sirtuin 1ENSG00000096717SIRT1chr10:67884669-67918390:+Tchem1855.98
adenylate cyclase 7ENSG00000121281ADCY7chr16:50246137-50318135:+Tbio25.8839
ATPase Na+/K+ transporting subunit beta 3ENSG00000069849ATP1B3chr3:141876124-141926514:+Tclin7.60119
deoxyribonuclease 1 like 2ENSG00000167968DNASE1L2chr16:2235816-2238711:+Tbio13.4262
proline and arginine rich end leucine rich repeat proteinENSG00000188783PRELPchr1:203475828-203491352:+Tbio22.3595
complement C8 gamma chainENSG00000176919C8Gchr9:136945246-136946974:+Tbio21.3325
HDGF like 1ENSG00000112273HDGFL1chr6:22569493-22571666:+Tdark1
phospholipase C eta 1ENSG00000114805PLCH1chr3:155375580-155745067:-Tbio3.08333
complement C3b/C4b receptor 1 likeENSG00000197721CR1Lchr1:207645113-207738416:+Tdark2.83707
H3 clustered histone 10ENSG00000278828HIST1H3Hchr6:27810064-27811300:+0
chromodomain Y likeENSG00000153046CDYLchr6:4706159-4955551:+Tbio9.25311
methionyl aminopeptidase 1ENSG00000164024METAP1chr4:98995620-99062813:+Tchem18.1667
butyrophilin like 3ENSG00000168903BTNL3chr5:180988845-181006727:+Tdark1
gamma-aminobutyric acid type A receptor subunit piENSG00000094755GABRPchr5:170763350-170814047:+Tclin9.44406
inter-alpha-trypsin inhibitor heavy chain 3ENSG00000162267ITIH3chr3:52794768-52809009:+Tbio15.3067
HGF activatorENSG00000109758HGFACchr4:3441887-3449495:+Tchem47.0687
G protein-coupled receptor 37 like 1ENSG00000170075GPR37L1chr1:202122858-202133592:+Tbio4.33333

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