PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| dermokine | ENSG00000161249 | DMKN | chr19:35497220-35513658:- | Tbio | 6.58333 |
| BPI fold containing family B member 1 | ENSG00000125999 | BPIFB1 | chr20:33273480-33309878:+ | Tbio | 16.9263 |
| apolipoprotein A4 | ENSG00000110244 | APOA4 | chr11:116820700-116823306:- | Tbio | 380.292 |
| retinol dehydrogenase 5 | ENSG00000135437 | RDH5 | chr12:55720367-55724705:+ | Tbio | 70.8293 |
| dual specificity phosphatase 3 | ENSG00000108861 | DUSP3 | chr17:43766121-43778988:- | Tchem | 112.548 |
| thimet oligopeptidase 1 | ENSG00000172009 | THOP1 | chr19:2785460-2815807:+ | Tbio | 37.0095 |
| leukotriene A4 hydrolase | ENSG00000111144 | LTA4H | chr12:96000828-96043520:- | Tchem | 246.895 |
| glutathione S-transferase mu 4 | ENSG00000168765 | GSTM4 | chr1:109656081-109674836:+ | Tbio | 20.0879 |
| serine protease 33 | ENSG00000103355 | PRSS33 | chr16:2783953-2787948:- | Tbio | 0 |
| lactase | ENSG00000115850 | LCT | chr2:135787840-135837180:- | Tbio | 1418.32 |
| D-aspartate oxidase | ENSG00000203797 | DDO | chr6:110391771-110415562:- | Tchem | 25.0664 |
| aph-1 homolog A, gamma-secretase subunit | ENSG00000117362 | APH1A | chr1:150265399-150269580:- | Tbio | 77.25 |
| pitrilysin metallopeptidase 1 | ENSG00000107959 | PITRM1 | chr10:3137728-3172841:- | Tchem | 160.825 |
| potassium voltage-gated channel modifier subfamily S member 3 | ENSG00000170745 | KCNS3 | chr2:17877847-18361616:+ | Tclin | 12.8084 |
| carbohydrate sulfotransferase 4 | ENSG00000140835 | CHST4 | chr16:71525233-71538746:+ | Tbio | 18.4053 |
| solute carrier family 13 member 3 | ENSG00000158296 | SLC13A3 | chr20:46557823-46684467:- | Tbio | 29.7952 |
| repetin | ENSG00000215853 | RPTN | chr1:152153595-152159228:- | Tbio | 17.4 |
| sialic acid binding Ig like lectin 9 | ENSG00000129450 | SIGLEC9 | chr19:51124908-51136651:+ | Tbio | 39.3745 |
| phosphodiesterase 7B | ENSG00000171408 | PDE7B | chr6:135851696-136195574:+ | Tclin | 19.3698 |
| calcium voltage-gated channel auxiliary subunit beta 1 | ENSG00000067191 | CACNB1 | chr17:39173456-39197703:- | Tbio | 9.58853 |
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