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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
solute carrier family 43 member 1	ENSG00000149150	SLC43A1	chr11:57484534-57515786:-	Tbio	7.70043
lysine demethylase 4B	ENSG00000127663	KDM4B	chr19:4969113-5153595:+	Tchem	28.43
H3 clustered histone 4	ENSG00000197409	HIST1H3D	chr6:26196840-26197250:-	Tbio	4.06667
PDLIM1 interacting kinase 1 like	ENSG00000175087	PDIK1L	chr1:26111165-26125543:+	Tdark	50.0179
short chain dehydrogenase/reductase family 9C member 7	ENSG00000170426	SDR9C7	chr12:56923154-56934405:-	Tbio	11.3706
SPG7 matrix AAA peptidase subunit, paraplegin	ENSG00000197912	SPG7	chr16:89490917-89557768:+	Tbio	139.611
quiescin sulfhydryl oxidase 2	ENSG00000165661	QSOX2	chr9:136206333-136245841:-	Tbio	4.92857
transcription factor 20	ENSG00000100207	TCF20	chr22:42160013-42343616:-	Tbio	102.8
Fc fragment of IgG binding protein	ENSG00000275395	FCGBP	chr19:39863323-39934626:-	Tbio	18.1421
solute carrier family 38 member 7	ENSG00000103042	SLC38A7	chr16:58665109-58685104:-	Tdark	0.742857
solute carrier family 2 member 6	ENSG00000160326	SLC2A6	chr9:133471095-133479137:-	Tbio	2.84286
CECR2 histone acetyl-lysine reader	ENSG00000099954	CECR2	chr22:17359949-17558149:+	Tchem	6.89444
Rab geranylgeranyltransferase subunit beta	ENSG00000137955	RABGGTB	chr1:75786197-75795079:+	Tbio	2.36667
ectonucleotide pyrophosphatase/phosphodiesterase 6	ENSG00000164303	ENPP6	chr4:184088706-184221230:-	Tbio	8.11111
dual serine/threonine and tyrosine protein kinase	ENSG00000133059	DSTYK	chr1:205142505-205211566:-	Tchem	5.47619
MORC family CW-type zinc finger 4	ENSG00000133131	MORC4	chrX:106813871-107000244:-	Tdark	3.9373
aldehyde dehydrogenase 1 family member B1	ENSG00000137124	ALDH1B1	chr9:38392664-38398661:+	Tbio	22.852
solute carrier family 5 member 10	ENSG00000154025	SLC5A10	chr17:18950345-19022595:+	Tbio	7.11667
aminoacylase 1	ENSG00000243989	ACY1	chr3:51983340-51989197:+	Tbio	147.938
calmodulin 3	ENSG00000160014	CALM3	chr19:46601074-46610793:+	Tclin	609.975

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