PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
phosphatidylinositol glycan anchor biosynthesis class FENSG00000151665PIGFchr2:46580937-46617119:-Tbio53.6235
N-acetylated alpha-linked acidic dipeptidase like 2ENSG00000177694NAALADL2chr3:174438573-175810552:+Tdark3.26071
PHD finger protein 19ENSG00000119403PHF19chr9:120855652-120894896:-Tbio62.4195
zinc finger MYND-type containing 8ENSG00000101040ZMYND8chr20:47209214-47356889:-Tbio6.09664
ATP binding cassette subfamily B member 8ENSG00000197150ABCB8chr7:151028422-151047782:+Tbio12.43
solute carrier family 6 member 12ENSG00000111181SLC6A12chr12:190077-214570:-Tchem41.7271
glutamate ionotropic receptor NMDA type subunit 2CENSG00000161509GRIN2Cchr17:74842023-74861504:-Tclin57.0122
collagen type XIII alpha 1 chainENSG00000197467COL13A1chr10:69801931-69964275:+Tbio16.4593
ribonuclease A family member 3ENSG00000169397RNASE3chr14:20891399-20892348:+Tbio714.802
elastin microfibril interfacer 2ENSG00000132205EMILIN2chr18:2847030-2915993:+Tdark10.1753
histone deacetylase 11ENSG00000163517HDAC11chr3:13479724-13506424:+Tclin45.064
PX domain containing serine/threonine kinase likeENSG00000168297PXKchr3:58332880-58426126:+Tbio12.8307
potassium inwardly rectifying channel subfamily J member 16ENSG00000153822KCNJ16chr17:70053429-70135608:+Tbio22.0786
SRSF protein kinase 3ENSG00000184343SRPK3chrX:153776412-153785732:+Tchem2.39286
CEA cell adhesion molecule 7ENSG00000007306CEACAM7chr19:41673307-41706976:-Tbio18.5694
aldo-keto reductase family 1 member A1ENSG00000117448AKR1A1chr1:45550543-45570049:+Tchem1228.03
leukocyte associated immunoglobulin like receptor 2ENSG00000167618LAIR2chr19:54497879-54510687:+Tbio13.9436
potassium inwardly rectifying channel subfamily J member 4ENSG00000168135KCNJ4chr22:38426327-38455199:-Tchem71.2023
serum amyloid A4, constitutiveENSG00000148965SAA4chr11:18112617-18236893:-Tbio47.2619
solute carrier family 35 member G1ENSG00000176273SLC35G1chr10:93893973-93956062:+Tbio1.66667

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