PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
cadherin EGF LAG seven-pass G-type receptor 2ENSG00000143126CELSR2chr1:109250019-109275750:+Tbio12.8059
leukocyte immunoglobulin like receptor A4ENSG00000239961LILRA4chr19:54333185-54339150:-Tbio12.1903
retinol dehydrogenase 16ENSG00000139547RDH16chr12:56951431-56959374:-Tbio8.66661
angiopoietin like 6ENSG00000130812ANGPTL6chr19:10092338-10102796:-Tbio37.7971
G protein-coupled receptor 183ENSG00000169508GPR183chr13:99294530-99307405:-Tchem22.9597
H1.0 linker histoneENSG00000189060H1F0chr22:37805093-37807436:+Tchem367.7
solute carrier family 9 member A5ENSG00000135740SLC9A5chr16:67237683-67272190:+Tbio16.3262
cyclin dependent kinase 14ENSG00000058091CDK14chr7:90466424-91210590:+Tchem20.4629
carboxypeptidase X, M14 family member 2ENSG00000121898CPXM2chr10:123706207-123940267:-Tbio1.94762
adhesion G protein-coupled receptor A2ENSG00000020181ADGRA2chr8:37784191-37844896:+Tbio17.0343
signal peptide, CUB domain and EGF like domain containing 1ENSG00000159307SCUBE1chr22:43197283-43343388:-Tbio24.3204
LIM domain kinase 2ENSG00000182541LIMK2chr22:31212239-31280080:+Tchem40.0532
solute carrier family 22 member 11ENSG00000168065SLC22A11chr11:64555626-64572875:+Tclin58.1602
sirtuin 2ENSG00000068903SIRT2chr19:38878555-38899862:-Tchem251.26
adenylate cyclase 4ENSG00000129467ADCY4chr14:24318349-24335093:-Tbio44.779
chromodomain helicase DNA binding protein 5ENSG00000116254CHD5chr1:6101793-6180123:-Tbio51.1932
cytokine receptor like factor 1ENSG00000006016CRLF1chr19:18572220-18607741:-Tbio79.4047
mucolipin 2ENSG00000153898MCOLN2chr1:84925583-84997113:-Tbio9.98069
hyaluronidase 2ENSG00000068001HYAL2chr3:50317790-50322906:-Tbio75.4017
guanylate cyclase activator 2BENSG00000044012GUCA2Bchr1:42153421-42155824:+Tbio90.5733

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