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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
collagen type XXVI alpha 1 chain	ENSG00000160963	COL26A1	chr7:101362820-101559024:+	Tdark	7.7
solute carrier family 18 member A3	ENSG00000187714	SLC18A3	chr10:49610301-49612720:+	Tchem	100.021
kelch like family member 15	ENSG00000174010	KLHL15	chrX:23983720-24027186:-	Tbio	2.90043
X-prolyl aminopeptidase 2	ENSG00000122121	XPNPEP2	chrX:129738974-129769538:+	Tchem	30.8845
carbonic anhydrase 13	ENSG00000185015	CA13	chr8:85220587-85284073:+	Tclin	37.1929
G protein-coupled receptor 18	ENSG00000125245	GPR18	chr13:99254714-99261744:-	Tbio	16.1445
potassium voltage-gated channel subfamily H member 6	ENSG00000173826	KCNH6	chr17:63523334-63548977:+	Tclin	16.4472
cathepsin O	ENSG00000256043	CTSO	chr4:155924118-155953917:-	Tbio	8.38333
kallikrein related peptidase 12	ENSG00000186474	KLK12	chr19:51029092-51035230:-	Tbio	17.3777
glutamate metabotropic receptor 8	ENSG00000179603	GRM8	chr7:126438598-127253294:-	Tchem	22.7582
tubulin delta 1	ENSG00000108423	TUBD1	chr17:59859482-59892945:-	Tbio	8.88803
endoplasmic reticulum aminopeptidase 2	ENSG00000164308	ERAP2	chr5:96875939-96919716:+	Tchem	51.8662
FKBP prolyl isomerase 7	ENSG00000079150	FKBP7	chr2:178463664-178478600:-	Tbio	20.6667
RAR related orphan receptor B	ENSG00000198963	RORB	chr9:74497365-74693177:+	Tchem	31.439
Fc receptor like 2	ENSG00000132704	FCRL2	chr1:157745733-157777132:-	Tbio	8.98997
tau tubulin kinase 1	ENSG00000146216	TTBK1	chr6:43243680-43288259:+	Tbio	11.2561
poly(ADP-ribose) polymerase 2	ENSG00000129484	PARP2	chr14:20343582-20357905:+	Tclin	66.8542
sialic acid binding Ig like lectin 7	ENSG00000168995	SIGLEC7	chr19:51142299-51153526:+	Tbio	56.3857
trophoblast glycoprotein	ENSG00000146242	TPBG	chr6:82363206-82370828:+	Tbio	50.679
oxoglutarate receptor 1	ENSG00000165621	OXGR1	chr13:96985719-96994730:-	Tbio	16.3733

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