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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
prostaglandin D2 receptor	ENSG00000168229	PTGDR	chr14:52267713-52276724:+	Tclin	409.717
ephrin B1	ENSG00000090776	EFNB1	chrX:68828997-68842147:+	Tbio	114.243
G protein-coupled receptor 1	ENSG00000183671	GPR1	chr2:206175316-206218047:-	Tbio	21.8957
glycogen phosphorylase L	ENSG00000100504	PYGL	chr14:50857891-50944736:-	Tchem	20.0612
NME/NM23 family member 9	ENSG00000181322	NME9	chr3:138261437-138329886:-	Tbio	6.08182
mannose receptor C type 2	ENSG00000011028	MRC2	chr17:62627401-62693597:+	Tbio	58.2609
fibulin 2	ENSG00000163520	FBLN2	chr3:13549131-13638422:+	Tbio	39.2948
AE binding protein 1	ENSG00000106624	AEBP1	chr7:44104361-44114562:+	Tbio	24.3478
serpin family B member 9	ENSG00000170542	SERPINB9	chr6:2887266-2903280:-	Tbio	112.081
glypican 4	ENSG00000076716	GPC4	chrX:133300103-133415490:-	Tbio	26.8813
cytochrome P450 family 2 subfamily C member 19	ENSG00000165841	CYP2C19	chr10:94762624-94853260:+	Tchem	2196.58
serine/threonine kinase 32C	ENSG00000165752	STK32C	chr10:132207492-132331847:-	Tbio	4.83333
aldo-keto reductase family 1 member B15	ENSG00000227471	AKR1B15	chr7:134549136-134579875:+	Tbio	1.5
collagen type IX alpha 2 chain	ENSG00000049089	COL9A2	chr1:40300487-40317816:-	Tbio	61.6327
CD101 molecule	ENSG00000134256	CD101	chr1:117001750-117036476:+	Tbio	28.1902
retinol dehydrogenase 10	ENSG00000121039	RDH10	chr8:73294612-73325281:+	Tbio	16.2488
gamma-aminobutyric acid type A receptor subunit gamma3	ENSG00000182256	GABRG3	chr15:26971282-27541991:+	Tclin	11.1761
histamine receptor H2	ENSG00000113749	HRH2	chr5:175658030-175686242:+	Tclin	82.9036
3-hydroxybutyrate dehydrogenase 2	ENSG00000164039	BDH2	chr4:103079435-103099883:-	Tbio	8.0119
aldehyde dehydrogenase 4 family member A1	ENSG00000159423	ALDH4A1	chr1:18871430-18902781:-	Tbio	15.3484

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