PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
heparan sulfate-glucosamine 3-sulfotransferase 1ENSG00000002587HS3ST1chr4:11393150-11429765:-Tbio14.8167
leucine rich repeat neuronal 3ENSG00000173114LRRN3chr7:111091006-111125454:+Tbio5.08571
lysine methyltransferase 5BENSG00000110066SUV420H1chr11:68154863-68213828:-Tbio10.4835
thymidine kinase 2ENSG00000166548TK2chr16:66508003-66552544:-Tchem111.054
sodium leak channel, non-selectiveENSG00000102452NALCNchr13:101053776-101416492:-Tbio22.1417
complement component 5a receptor 2ENSG00000134830C5AR2chr19:47332147-47347327:+Tbio51.2155
serine peptidase inhibitor Kazal type 2ENSG00000128040SPINK2chr4:56809860-56821742:-Tdark11.9622
serine peptidase inhibitor Kazal type 7ENSG00000145879SPINK7chr5:148312419-148315922:+Tbio50.0274
sodium voltage-gated channel alpha subunit 3ENSG00000153253SCN3Achr2:165087522-165204067:-Tclin50.7055
neural EGFL like 2ENSG00000184613NELL2chr12:44508275-44921848:-Tbio14.3079
phosphodiesterase 12ENSG00000174840PDE12chr3:57556276-57566844:+Tbio12.45
thioredoxin domain containing 12ENSG00000117862TXNDC12chr1:52020131-52056171:-Tbio51.1036
remodeling and spacing factor 1ENSG00000048649RSF1chr11:77659996-77821017:-Tbio51.4147
casein kinase 1 deltaENSG00000141551CSNK1Dchr17:82239023-82273731:-Tchem41.4087
solute carrier family 5 member 11ENSG00000158865SLC5A11chr16:24845841-24911628:+Tchem12.5043
integrin subunit alpha EENSG00000083457ITGAEchr17:3714628-3801243:-Tbio130.289
transmembrane p24 trafficking protein 10ENSG00000170348TMED10chr14:75131470-75176631:-Tbio38.1617
ectonucleoside triphosphate diphosphohydrolase 1ENSG00000138185ENTPD1chr10:95711779-95877266:+Tbio299.242
kelch repeat and BTB domain containing 11ENSG00000176595KBTBD11chr8:1973878-2006936:+Tdark0.071429
purinergic receptor P2X 6ENSG00000099957P2RX6chr22:21009808-21028830:+Tbio18.3462

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