PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| nectin cell adhesion molecule 2 | ENSG00000130202 | PVRL2 | chr19:44846175-44889228:+ | Tbio | 42.92 |
| apolipoprotein L1 | ENSG00000100342 | APOL1 | chr22:36253010-36267530:+ | Tbio | 53.1028 |
| microtubule associated serine/threonine kinase family member 4 | ENSG00000069020 | MAST4 | chr5:66596361-67169595:+ | Tbio | 10.4143 |
| G2/M-phase specific E3 ubiquitin protein ligase | ENSG00000092140 | G2E3 | chr14:30559123-30620063:+ | Tbio | 3.25 |
| proprotein convertase subtilisin/kexin type 6 | ENSG00000140479 | PCSK6 | chr15:101297142-101525202:- | Tchem | 90.7766 |
| thromboxane A synthase 1 | ENSG00000059377 | TBXAS1 | chr7:139777051-140020325:+ | Tchem | 91.1231 |
| sodium voltage-gated channel alpha subunit 7 | ENSG00000136546 | SCN7A | chr2:166403573-166494247:- | Tclin | 30.6401 |
| ribonuclease T2 | ENSG00000026297 | RNASET2 | chr6:166929504-166957191:- | Tbio | 78.4857 |
| myelin protein zero like 3 | ENSG00000160588 | MPZL3 | chr11:118226690-118252350:- | Tbio | 2.25 |
| peptidylprolyl isomerase F | ENSG00000108179 | PPIF | chr10:79347469-79355337:+ | Tchem | 117.119 |
| stimulator of chondrogenesis 1 | ENSG00000164106 | SCRG1 | chr4:173384701-173406380:- | Tdark | 3.05278 |
| kalirin RhoGEF kinase | ENSG00000160145 | KALRN | chr3:124080023-124726325:+ | Tbio | 38.8197 |
| protein tyrosine phosphatase receptor type K | ENSG00000152894 | PTPRK | chr6:127968779-128520674:- | Tbio | 28.2115 |
| gamma-aminobutyric acid type A receptor subunit alpha1 | ENSG00000022355 | GABRA1 | chr5:161847191-161899969:+ | Tclin | 97.1843 |
| kelch like family member 13 | ENSG00000003096 | KLHL13 | chrX:117897813-118117340:- | Tdark | 1.45 |
| protein kinase C eta | ENSG00000027075 | PRKCH | chr14:61187559-61550976:+ | Tchem | 61.0349 |
| NIMA related kinase 11 | ENSG00000114670 | NEK11 | chr3:131026850-131350465:+ | Tbio | 5.60833 |
| HtrA serine peptidase 4 | ENSG00000169495 | HTRA4 | chr8:38974164-38988662:+ | Tbio | 5.21945 |
| glutamate ionotropic receptor delta type subunit 1 | ENSG00000182771 | GRID1 | chr10:85599555-86366493:- | Tbio | 10.2296 |
| solute carrier family 16 member 9 | ENSG00000165449 | SLC16A9 | chr10:59650761-59736002:- | Tbio | 6.75079 |
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