PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
mucin like 1ENSG00000172551MUCL1chr12:54830519-54858393:+Tbio10
cyclic nucleotide gated channel subunit beta 1ENSG00000070729CNGB1chr16:57882340-57971116:-Tbio36.8956
butyrophilin like 8ENSG00000113303BTNL8chr5:180899077-180950906:+Tdark1.83333
cytochrome P450 family 2 subfamily S member 1ENSG00000167600CYP2S1chr19:41193049-41207539:+Tbio32.1033
ATPase phospholipid transporting 11AENSG00000068650ATP11Achr13:112690329-112887168:+Tbio5.41228
hyperpolarization activated cyclic nucleotide gated potassium channel 3ENSG00000143630HCN3chr1:155277583-155289848:+Tclin16.2802
guanylate cyclase 2CENSG00000070019GUCY2Cchr12:14612632-14696585:-Tclin301.183
slingshot protein phosphatase 2ENSG00000141298SSH2chr17:29625938-29930276:-Tbio3.64359
glypican 2ENSG00000213420GPC2chr7:100169606-100177372:-Tbio4.65238
solute carrier family 12 member 7ENSG00000113504SLC12A7chr5:1050376-1112035:-Tbio19.3143
dipeptidyl peptidase 3ENSG00000254986DPP3chr11:66480013-66509657:+Tbio74.2031
neuropeptide WENSG00000183971NPWchr16:2009926-2020755:+Tbio18.7663
chromobox 8ENSG00000141570CBX8chr17:79792132-79801683:-Tchem1111.57
kelch like family member 30ENSG00000168427KLHL30chr2:238138722-238152947:+Tdark0.1
major histocompatibility complex, class II, DO betaENSG00000241106HLA-DOBchr6:32812763-32817048:-Tbio43.6345
DiGeorge syndrome critical region gene 6ENSG00000183628DGCR6chr22:18906028-18914238:+Tbio14.0232
solute carrier family 35 member A1ENSG00000164414SLC35A1chr6:87470623-87512336:+Tbio11.4762
lysozyme g1ENSG00000144214LYG1chr2:99284238-99304742:-Tdark2
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseENSG00000100060MFNGchr22:37469063-37486401:-Tbio5.50357
urocortin 3ENSG00000178473UCN3chr10:5365009-5374692:+Tbio221.203

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