PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
G protein-coupled receptor 132ENSG00000183484GPR132chr14:105049389-105065445:-Tbio48.1033
C-type lectin domain family 4 member MENSG00000104938CLEC4Mchr19:7763149-7769605:+Tbio136.349
procollagen C-endopeptidase enhancerENSG00000106333PCOLCEchr7:100602177-100608175:+Tbio44.1028
solute carrier family 22 member 17ENSG00000092096SLC22A17chr14:23346306-23352912:-Tbio13.475
EGF containing fibulin extracellular matrix protein 2ENSG00000172638EFEMP2chr11:65866441-65873592:-Tbio38.2143
Rh family C glycoproteinENSG00000140519RHCGchr15:89471398-89496613:-Tbio51.8275
dual specificity tyrosine phosphorylation regulated kinase 3ENSG00000143479DYRK3chr1:206635536-206684419:+Tchem13.0957
mitogen-activated protein kinase kinase kinase 4ENSG00000085511MAP3K4chr6:160991727-161117385:+Tbio49.361
semaphorin 6BENSG00000167680SEMA6Bchr19:4542593-4559808:-Tbio14.4582
dicarbonyl and L-xylulose reductaseENSG00000169738DCXRchr17:82035136-82037732:-Tbio42.9986
transmembrane p24 trafficking protein 9ENSG00000184840TMED9chr5:177592158-177596124:+Tdark11.229
eukaryotic elongation factor 2 kinaseENSG00000103319EEF2Kchr16:22206282-22288732:+Tbio86.8984
mitogen-activated protein kinase 6ENSG00000069956MAPK6chr15:51952106-52067372:+Tbio20.3865
staphylococcal nuclease and tudor domain containing 1ENSG00000197157SND1chr7:127652180-128092609:+Tbio51.7131
retinol dehydrogenase 13ENSG00000160439RDH13chr19:55039108-55071291:-Tdark1.825
transmembrane serine protease 11AENSG00000187054TMPRSS11Achr4:67909385-67964140:-Tbio16.7976
ATP/GTP binding protein like 3ENSG00000146856AGBL3chr7:134986508-135147963:+Tbio25.8202
ADAM metallopeptidase with thrombospondin type 1 motif 7ENSG00000136378ADAMTS7chr15:78759203-78811431:-Tbio15.9218
prolylcarboxypeptidaseENSG00000137509PRCPchr11:82823502-82970584:-Tchem216.938
protein kinase cGMP-dependent 2ENSG00000138669PRKG2chr4:81087370-81215117:-Tchem36.9996

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