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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
collagen type XX alpha 1 chain	ENSG00000101203	COL20A1	chr20:63293186-63334851:+	Tdark	11.8922
fibroblast growth factor 5	ENSG00000138675	FGF5	chr4:80266599-80336680:+	Tbio	63.1595
reticulon 3	ENSG00000133318	RTN3	chr11:63681446-63759891:+	Tbio	85.1464
pelota mRNA surveillance and ribosome rescue factor	ENSG00000152684	PELO	chr5:52787940-52804046:+	Tbio	9.41075
cation channel sperm associated 2	ENSG00000166762	CATSPER2	chr15:43628503-43668118:-	Tchem	9.05556
cyclin dependent kinase like 1	ENSG00000100490	CDKL1	chr14:50329404-50416461:-	Tchem	34.9921
dehydrogenase/reductase 7B	ENSG00000109016	DHRS7B	chr17:21123364-21193265:+	Tdark	0
ATP binding cassette subfamily C member 10	ENSG00000124574	ABCC10	chr6:43427366-43450430:+	Tbio	38.0026
G protein-coupled receptor 161	ENSG00000143147	GPR161	chr1:168079543-168137667:-	Tbio	52.3536
PHD finger protein 14	ENSG00000106443	PHF14	chr7:10973872-11169623:+	Tbio	2.06944
solute carrier family 35 member F2	ENSG00000110660	SLC35F2	chr11:107790991-107928293:-	Tdark	5.42064
MAM domain containing 2	ENSG00000165072	MAMDC2	chr9:70043581-70226970:+	Tdark	0.583333
contactin associated protein family member 5	ENSG00000155052	CNTNAP5	chr2:124025287-124915287:+	Tdark	4.47454
inter-alpha-trypsin inhibitor heavy chain family member 6	ENSG00000102313	ITIH6	chrX:54748899-54798240:-	Tdark	0
peptidoglycan recognition protein 4	ENSG00000163218	PGLYRP4	chr1:153330120-153348840:-	Tbio	5.46349
complement C1q A chain	ENSG00000173372	C1QA	chr1:22636506-22639608:+	Tbio	2440.86
pleckstrin homology domain interacting protein	ENSG00000146247	PHIP	chr6:78935867-79078236:-	Tbio	73.0861
ecotropic viral integration site 2B	ENSG00000185862	EVI2B	chr17:31303766-31314112:-	Tbio	4.60994
ADAM like decysin 1	ENSG00000134028	ADAMDEC1	chr8:24384285-24406013:+	Tbio	10.505
C-C motif chemokine ligand 14	ENSG00000276409	CCL14	chr17:35983291-35987004:-	Tbio	261.883

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