PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ELOVL fatty acid elongase 6ENSG00000170522ELOVL6chr4:110045846-110199199:-Tchem52.9122
phosphodiesterase 10AENSG00000112541PDE10Achr6:165327287-165986603:-Tclin92.6808
follistatin like 5ENSG00000168843FSTL5chr4:161383897-162164035:-Tbio4.33333
ATPase phospholipid transporting 8B2ENSG00000143515ATP8B2chr1:154325553-154351307:+Tdark1.76389
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1ENSG00000277494GPIHBP1chr8:143213193-143217170:+Tbio42.0409
potassium voltage-gated channel subfamily C member 1ENSG00000129159KCNC1chr11:17734812-17783055:+Tclin108.249
ATP binding cassette subfamily A member 13ENSG00000179869ABCA13chr7:48171458-48647496:+Tbio12.4611
Fc receptor like AENSG00000132185FCRLAchr1:161706972-161714352:+Tbio30.8583
ATPase 13A4ENSG00000127249ATP13A4chr3:193402077-193593111:-Tdark2.34488
U2AF homology motif kinase 1ENSG00000152332UHMK1chr1:162497251-162529629:+Tbio58.4133
corin, serine peptidaseENSG00000145244CORINchr4:47593998-47838106:-Tbio129.73
solute carrier family 6 member 14ENSG00000268104SLC6A14chrX:116436622-116461458:+Tbio25.7821
cyclin dependent kinase 18ENSG00000117266CDK18chr1:205504595-205532793:+Tchem10.4383
tenascin NENSG00000120332TNNchr1:175067858-175148066:+Tbio7.28333
cholinergic receptor nicotinic alpha 9 subunitENSG00000174343CHRNA9chr4:40335329-40355217:+Tbio10.1274
natriuretic peptide BENSG00000120937NPPBchr1:11857464-11858931:-Tbio5280.47
ATPase phospholipid transporting 9B (putative)ENSG00000166377ATP9Bchr18:79069285-79378283:+Tdark26.2736
estrogen receptor 2ENSG00000140009ESR2chr14:64084232-64338112:-Tclin2681.61
free fatty acid receptor 2ENSG00000126262FFAR2chr19:35443907-35451767:+Tbio60.4702
killer cell lectin like receptor K1ENSG00000213809KLRK1chr12:10372353-10391874:-Tbio697.442

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