PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
interleukin 18 binding proteinENSG00000137496IL18BPchr11:71998541-72005715:+Tbio69.8854
cytochrome P450 family 4 subfamily X member 1ENSG00000186377CYP4X1chr1:47023568-47050751:+Tbio2.88976
leucine rich repeat neuronal 1ENSG00000175928LRRN1chr3:3799437-3847703:+Tdark3.96084
laminin subunit beta 4ENSG00000091128LAMB4chr7:108023548-108130356:-Tbio4.50758
neuron derived neurotrophic factorENSG00000173376NDNFchr4:121035613-121073021:-Tbio14.6833
transmembrane serine protease 11EENSG00000087128TMPRSS11Echr4:68447449-68497604:+Tbio6.66667
CD160 moleculeENSG00000117281CD160chr1:145719471-145739288:+Tbio49.8631
CCR4-NOT transcription complex subunit 6 likeENSG00000138767CNOT6Lchr4:77713387-77819615:-Tbio4.55192
gamma-aminobutyric acid type A receptor subunit beta3ENSG00000166206GABRB3chr15:26543546-26939539:-Tclin138.849
solute carrier family 46 member 1ENSG00000076351SLC46A1chr17:28394756-28407197:-Tchem144.724
transmembrane serine protease 11DENSG00000153802TMPRSS11Dchr4:67820876-67884032:-Tchem42.8667
ABI family member 3 binding proteinENSG00000154175ABI3BPchr3:100749156-100993515:-Tbio9.36993
solute carrier family 25 member 26ENSG00000144741SLC25A26chr3:66133610-66388116:+Tbio19.3147
ATP binding cassette subfamily B member 10ENSG00000135776ABCB10chr1:229516582-229558695:-Tbio13.8826
follistatin like 3ENSG00000070404FSTL3chr19:676365-683399:+Tbio58.0079
protein disulfide isomerase family A member 4ENSG00000155660PDIA4chr7:149003062-149028641:-Tbio30.0149
inter-alpha-trypsin inhibitor heavy chain 2ENSG00000151655ITIH2chr10:7703269-7749520:+Tbio10.7812
interleukin 17AENSG00000112115IL17Achr6:52186387-52190638:+Tclin2471.29
NIMA related kinase 1ENSG00000137601NEK1chr4:169393275-169612629:-Tchem25.8206
aldehyde dehydrogenase 3 family member B2ENSG00000132746ALDH3B2chr11:67662162-67681200:-Tbio1.5

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