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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
cerebral dopamine neurotrophic factor	ENSG00000185267	CDNF	chr10:14819250-14838575:-	Tbio	16.1929
integrin subunit beta 7	ENSG00000139626	ITGB7	chr12:53191318-53207307:-	Tclin	20.7949
BCL2 like 10	ENSG00000137875	BCL2L10	chr15:52109263-52112775:-	Tchem	47.0925
serine peptidase inhibitor Kazal type 4	ENSG00000122711	SPINK4	chr9:33218365-33248567:+	Tdark	14.6444
cytochrome P450 family 4 subfamily F member 12	ENSG00000186204	CYP4F12	chr19:15672757-15697174:+	Tdark	16.673
G protein-coupled receptor 157	ENSG00000180758	GPR157	chr1:9100305-9129170:-	Tdark	1.08333
solute carrier family 28 member 3	ENSG00000197506	SLC28A3	chr9:84275457-84340683:-	Tbio	62.991
ADAM metallopeptidase domain 23	ENSG00000114948	ADAM23	chr2:206443539-206621130:+	Tbio	24.4165
solute carrier family 30 member 10	ENSG00000196660	SLC30A10	chr1:219685427-219958647:-	Tbio	95.3575
angiopoietin like 3	ENSG00000132855	ANGPTL3	chr1:62597487-62606159:+	Tbio	67.6248
protein phosphatase 5 catalytic subunit	ENSG00000011485	PPP5C	chr19:46346994-46392981:+	Tbio	109.496
adhesion G protein-coupled receptor A1	ENSG00000197177	ADGRA1	chr10:133070929-133131675:+	Tdark	2.96166
chondroadherin	ENSG00000136457	CHAD	chr17:50464496-50468966:-	Tbio	50.2111
endoplasmic reticulum metallopeptidase 1	ENSG00000099219	ERMP1	chr9:5765076-5833117:-	Tdark	0.166667
hemicentin 1	ENSG00000143341	HMCN1	chr1:185734551-186190949:+	Tbio	22.9
apoptosis associated tyrosine kinase	ENSG00000181409	AATK	chr17:81117295-81166077:-	Tbio	11.9345
leucine rich repeat containing 26	ENSG00000184709	LRRC26	chr9:137168758-137170051:-	Tbio	20.7333
RNA polymerase II subunit C	ENSG00000102978	POLR2C	chr16:57462387-57472010:+	Tbio	11.6
Kazal type serine peptidase inhibitor domain 1	ENSG00000107821	KAZALD1	chr10:101061841-101068131:+	Tdark	4.52143
potassium voltage-gated channel subfamily B member 2	ENSG00000182674	KCNB2	chr8:72537391-72938349:+	Tclin	11.5751

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