PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
| Showing page 160 |
first page | previous page | next page | last page |
| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| left-right determination factor 2 | ENSG00000143768 | LEFTY2 | chr1:225936598-225941489:- | Tbio | 35.2339 |
| adhesion G protein-coupled receptor L2 | ENSG00000117114 | ADGRL2 | chr1:81306160-81992436:+ | Tbio | 133.518 |
| solute carrier family 15 member 2 | ENSG00000163406 | SLC15A2 | chr3:121894089-121944102:+ | Tbio | 81.6211 |
| SET and MYND domain containing 4 | ENSG00000186532 | SMYD4 | chr17:1779485-1830634:- | Tdark | 1.33333 |
| glutathione S-transferase kappa 1 | ENSG00000197448 | GSTK1 | chr7:143244093-143270854:+ | Tchem | 2053.61 |
| ribosomal protein S6 kinase A6 | ENSG00000072133 | RPS6KA6 | chrX:84058346-84187907:- | Tchem | 26.3238 |
| hydroxyacylglutathione hydrolase | ENSG00000063854 | HAGH | chr16:1795620-1827194:- | Tbio | 115.277 |
| heat shock protein family H (Hsp110) member 1 | ENSG00000120694 | HSPH1 | chr13:31134974-31162388:- | Tbio | 38.7266 |
| A-Raf proto-oncogene, serine/threonine kinase | ENSG00000078061 | ARAF | chrX:47561100-47571920:+ | Tchem | 103.852 |
| synaptosome associated protein 29 | ENSG00000099940 | SNAP29 | chr22:20858983-20891218:+ | Tbio | 25.9456 |
| retinol binding protein 5 | ENSG00000139194 | RBP5 | chr12:7123684-7128942:- | Tbio | 5.83333 |
| N-acetylated alpha-linked acidic dipeptidase 2 | ENSG00000077616 | NAALAD2 | chr11:90131515-90192894:+ | Tchem | 2.06111 |
| tolloid like 1 | ENSG00000038295 | TLL1 | chr4:165873258-166103895:+ | Tbio | 60.4884 |
| hyaluronidase 3 | ENSG00000186792 | HYAL3 | chr3:50292828-50299468:- | Tbio | 16.0687 |
| potassium voltage-gated channel modifier subfamily G member 1 | ENSG00000026559 | KCNG1 | chr20:51003656-51023129:- | Tclin | 27.9112 |
| cyclin dependent kinase 10 | ENSG00000185324 | CDK10 | chr16:89680737-89696364:+ | Tbio | 26.419 |
| zinc metallopeptidase STE24 | ENSG00000084073 | ZMPSTE24 | chr1:40258107-40294184:+ | Tbio | 102.593 |
| solute carrier family 16 member 12 | ENSG00000152779 | SLC16A12 | chr10:89430299-89556641:- | Tbio | 9.53593 |
| dehydrogenase/reductase 3 | ENSG00000162496 | DHRS3 | chr1:12567910-12617731:- | Tbio | 18.5056 |
| complement factor H related 1 | ENSG00000244414 | CFHR1 | chr1:196819757-196832189:+ | Tbio | 149.333 |
|
Showing page 160 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.