PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| CD300a molecule | ENSG00000167851 | CD300A | chr17:74466416-74484796:+ | Tbio | 49.5171 |
| insulin receptor related receptor | ENSG00000027644 | INSRR | chr1:156840063-156859018:- | Tchem | 702.435 |
| bone morphogenetic protein 5 | ENSG00000112175 | BMP5 | chr6:55753645-55875564:- | Tbio | 36.3063 |
| solute carrier family 25 member 15 | ENSG00000102743 | SLC25A15 | chr13:40789412-40810111:+ | Tbio | 42.0333 |
| lipase family member M | ENSG00000173239 | LIPM | chr10:88802730-88820546:+ | Tbio | 3.43333 |
| sulfatase 2 | ENSG00000196562 | SULF2 | chr20:47656348-47786616:- | Tbio | 52.4277 |
| cyclic nucleotide gated channel subunit alpha 3 | ENSG00000144191 | CNGA3 | chr2:98346155-98398601:+ | Tbio | 75.228 |
| signal sequence receptor subunit 2 | ENSG00000163479 | SSR2 | chr1:156009048-156020959:- | Tbio | 25.7333 |
| otospiralin | ENSG00000178602 | OTOS | chr2:240139026-240144562:- | Tdark | 3.5 |
| sucrase-isomaltase | ENSG00000090402 | SI | chr3:164978898-165078495:- | Tchem | 23.5833 |
| semaphorin 3D | ENSG00000153993 | SEMA3D | chr7:84995553-85186855:- | Tbio | 15.4204 |
| collagen type XVI alpha 1 chain | ENSG00000084636 | COL16A1 | chr1:31652247-31704319:- | Tbio | 2.84643 |
| solute carrier family 25 member 23 | ENSG00000125648 | SLC25A23 | chr19:6436079-6465203:- | Tbio | 5.54762 |
| ATPase phospholipid transporting 8B4 (putative) | ENSG00000104043 | ATP8B4 | chr15:49858238-50182817:- | Tdark | 2.00833 |
| peptidase, mitochondrial processing subunit beta | ENSG00000105819 | PMPCB | chr7:103297422-103329511:+ | Tbio | 10.9198 |
| methionyl aminopeptidase 2 | ENSG00000111142 | METAP2 | chr12:95473520-95515839:+ | Tchem | 86.9539 |
| Ras converting CAAX endopeptidase 1 | ENSG00000173653 | RCE1 | chr11:66842835-66846546:+ | Tchem | 30.2956 |
| cytochrome P450 family 4 subfamily Z member 1 | ENSG00000186160 | CYP4Z1 | chr1:47067488-47118319:+ | Tbio | 5.57613 |
| galectin 7B | ENSG00000178934 | LGALS7B | chr19:38789211-38791749:+ | Tbio | 10.9206 |
| Rh blood group D antigen | ENSG00000187010 | RHD | chr1:25272393-25330445:+ | Tbio | 1215.63 |
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