PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| calpain 5 | ENSG00000149260 | CAPN5 | chr11:77066932-77126155:+ | Tbio | 44.7094 |
| sulfite oxidase | ENSG00000139531 | SUOX | chr12:55997180-56006641:+ | Tbio | 138.9 |
| hydroxysteroid 17-beta dehydrogenase 12 | ENSG00000149084 | HSD17B12 | chr11:43556436-43856617:+ | Tbio | 18.7949 |
| DEAF1 transcription factor | ENSG00000177030 | DEAF1 | chr11:644233-706715:- | Tbio | 198.376 |
| carboxypeptidase A3 | ENSG00000163751 | CPA3 | chr3:148865256-148897196:+ | Tchem | 22.9579 |
| interleukin 17 receptor A | ENSG00000177663 | IL17RA | chr22:17084954-17115694:+ | Tclin | 90.3186 |
| serine/threonine kinase 25 | ENSG00000115694 | STK25 | chr2:241492674-241509730:- | Tchem | 17.1842 |
| microsomal glutathione S-transferase 1 | ENSG00000008394 | MGST1 | chr12:16347142-16609259:+ | Tbio | 66.9718 |
| phosphoinositide-3-kinase interacting protein 1 | ENSG00000100100 | PIK3IP1 | chr22:31281593-31292534:- | Tbio | 9.62778 |
| WNK lysine deficient protein kinase 3 | ENSG00000196632 | WNK3 | chrX:54192823-54358642:- | Tbio | 13.7952 |
| prolactin releasing hormone receptor | ENSG00000119973 | PRLHR | chr10:118589989-118595699:- | Tchem | 29.8255 |
| dipeptidyl peptidase 7 | ENSG00000176978 | DPP7 | chr9:137110542-137115177:- | Tchem | 91.2707 |
| FAM3 metabolism regulating signaling molecule B | ENSG00000183844 | FAM3B | chr21:41304212-41357431:+ | Tbio | 91.9234 |
| caseinolytic mitochondrial matrix peptidase proteolytic subunit | ENSG00000125656 | CLPP | chr19:6361452-6368908:+ | Tbio | 107.924 |
| 1,4-alpha-glucan branching enzyme 1 | ENSG00000114480 | GBE1 | chr3:81489699-81762161:- | Tbio | 102.907 |
| semaphorin 3C | ENSG00000075223 | SEMA3C | chr7:80742538-80922359:- | Tbio | 33.2636 |
| notum, palmitoleoyl-protein carboxylesterase | ENSG00000185269 | NOTUM | chr17:81952507-81961840:- | Tchem | 6.02143 |
| arylsulfatase family member K | ENSG00000164291 | ARSK | chr5:95555074-95605064:+ | Tdark | 104.676 |
| sirtuin 3 | ENSG00000142082 | SIRT3 | chr11:215458-236931:- | Tchem | 219.933 |
| adenosylmethionine decarboxylase 1 | ENSG00000123505 | AMD1 | chr6:110814621-110895713:+ | Tchem | 152.936 |
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