PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
protein O-mannose kinaseENSG00000185900POMKchr8:43093506-43123434:+Tdark2.66667
farnesyltransferase, CAAX box, betaENSG00000257365FNTBchr14:64986720-65062652:+Tbio3.49444
Fc receptor like 1ENSG00000163534FCRL1chr1:157794403-157820105:-Tbio12.5467
aldehyde dehydrogenase 6 family member A1ENSG00000119711ALDH6A1chr14:74056850-74084493:-Tbio9.09718
solute carrier family 27 member 2ENSG00000140284SLC27A2chr15:50182196-50236395:+Tbio27.1421
contactin 4ENSG00000144619CNTN4chr3:2098813-3057956:+Tbio46.8915
major facilitator superfamily domain containing 2AENSG00000168389MFSD2Achr1:39955112-39969968:+Tbio36.5317
carbonic anhydrase 11ENSG00000063180CA11chr19:48637942-48646312:-Tbio28.0444
ring finger protein 31ENSG00000092098RNF31chr14:24146683-24160661:+Tbio24.554
rhomboid like 2ENSG00000158315RHBDL2chr1:38885807-38941799:-Tbio10.9762
netrin 4ENSG00000074527NTN4chr12:95657807-95791152:-Tbio28.3191
solute carrier family 6 member 1ENSG00000157103SLC6A1chr3:10992724-11039247:+Tclin192.737
aminopeptidase puromycin sensitiveENSG00000141279NPEPPSchr17:47522942-47623276:+Tbio770.023
sialic acid acetylesteraseENSG00000110013SIAEchr11:124633113-124695707:-Tbio44.2436
complement component 4 binding protein betaENSG00000123843C4BPBchr1:207088842-207099993:+Tbio16.8917
ficolin 2ENSG00000160339FCN2chr9:134880812-134887520:+Tbio133.814
solute carrier family 35 member A2ENSG00000102100SLC35A2chrX:48903182-48911958:-Tbio22.8506
phosphoribosyl pyrophosphate synthetase 1ENSG00000147224PRPS1chrX:107628424-107651026:+Tbio72.0159
FMR1 autosomal homolog 1ENSG00000114416FXR1chr3:180868141-180982753:+Tbio36.9797
arylsulfatase family member JENSG00000180801ARSJchr4:113900284-113979727:-Tdark0.7

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