PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 12 member 6ENSG00000140199SLC12A6chr15:34229996-34338060:-Tbio39.0325
gamma-aminobutyric acid type A receptor subunit gamma2ENSG00000113327GABRG2chr5:162067540-162155536:+Tclin149.174
collectrin, amino acid transport regulatorENSG00000147003TMEM27chrX:15627318-15665031:-Tbio15.0484
unc-51 like autophagy activating kinase 2ENSG00000083290ULK2chr17:19770829-19867936:-Tchem7.21936
ribonuclease A family member 1, pancreaticENSG00000129538RNASE1chr14:20801228-20803278:-Tchem961.64
peptidoglycan recognition protein 3ENSG00000159527PGLYRP3chr1:153297862-153310718:-Tbio9.58571
G protein-coupled receptor 19ENSG00000183150GPR19chr12:12660891-12696207:-Tbio3.30786
phosphodiesterase 4CENSG00000105650PDE4Cchr19:18207961-18255419:-Tclin16.4673
sphingosine-1-phosphate receptor 5ENSG00000180739S1PR5chr19:10512742-10517931:-Tclin25.9484
solute carrier family 13 member 5ENSG00000141485SLC13A5chr17:6684713-6713567:-Tchem77.3026
hydroxysteroid 17-beta dehydrogenase 13ENSG00000170509HSD17B13chr4:87303789-87322906:-Tdark37.5112
solute carrier family 35 member F3ENSG00000183780SLC35F3chr1:233904933-234324516:+Tbio3.11111
solute carrier family 22 member 4ENSG00000197208SLC22A4chr5:132294443-132344206:+Tbio142.573
fibrinogen like 1ENSG00000104760FGL1chr8:17864380-17910365:-Tbio17
tubulin alpha 3dENSG00000075886TUBA3Dchr2:131476093-131482934:+0
leucine rich repeat containing 55ENSG00000183908LRRC55chr11:57181747-57191717:+Tbio0.65
solute carrier family 23 member 1ENSG00000170482SLC23A1chr5:139367196-139384553:-Tbio61.9925
thioredoxin like 1ENSG00000091164TXNL1chr18:56597208-56651600:-Tbio47.0999
microfibril associated protein 1ENSG00000140259MFAP1chr15:43804492-43824802:-Tbio2.94444
glutamate ionotropic receptor delta type subunit 2ENSG00000152208GRID2chr4:92303622-93774556:+Tbio14.7211

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