PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
carbonyl reductase 1ENSG00000159228CBR1chr21:36069941-36073166:+Tchem271.339
angiopoietin like 1ENSG00000116194ANGPTL1chr1:178849705-178871052:-Tbio12.9421
cytochrome P450 family 27 subfamily C member 1ENSG00000186684CYP27C1chr2:127184120-127220078:-Tbio1.33333
ATPase H+/K+ transporting non-gastric alpha2 subunitENSG00000075673ATP12Achr13:24680411-24712493:+Tchem77.5762
secretogranin IIIENSG00000104112SCG3chr15:51681353-51721031:+Tbio29.5629
scavenger receptor class A member 5ENSG00000168079SCARA5chr8:27869882-27992727:-Tbio11.3651
alcohol dehydrogenase 6 (class V)ENSG00000172955ADH6chr4:99202638-99219537:-Tbio17.3686
mitogen-activated protein kinase kinase kinase 11ENSG00000173327MAP3K11chr11:65597755-65615382:-Tchem91.9201
energy homeostasis associatedENSG00000168913ENHOchr9:34521040-34523041:-Tbio12.0833
ATP synthase membrane subunit fENSG00000241468ATP5J2chr7:99448475-99466331:-Tbio2.49059
tripartite motif containing 16 likeENSG00000108448TRIM16Lchr17:18697998-18736118:+Tdark0
solute carrier family 39 member 14ENSG00000104635SLC39A14chr8:22367249-22434129:+Tbio28.8665
serum/glucocorticoid regulated kinase 2ENSG00000101049SGK2chr20:43558968-43588237:+Tbio7.79216
protein tyrosine phosphatase receptor type JENSG00000149177PTPRJchr11:47980558-48170841:+Tbio151.253
semaphorin 4BENSG00000185033SEMA4Bchr15:90160604-90229679:+Tbio8.52143
cellular repressor of E1A stimulated genes 2ENSG00000175874CREG2chr2:101345551-101387595:-Tdark0.75
acylaminoacyl-peptide hydrolaseENSG00000164062APEHchr3:49674002-49683963:+Tbio213.582
cell growth regulator with EF-hand domain 1ENSG00000138028CGREF1chr2:27098889-27119115:-Tbio0.748607
G protein-coupled receptor 153ENSG00000158292GPR153chr1:6247346-6260975:-Tdark3.61825
glucosamine (N-acetyl)-6-sulfataseENSG00000135677GNSchr12:64713445-64759447:-Tbio15.3333

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