PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ADAM metallopeptidase domain 28ENSG00000042980ADAM28chr8:24294040-24359018:+Tbio48.9743
solute carrier family 4 member 1 (Diego blood group)ENSG00000004939SLC4A1chr17:44248385-44268141:-Tbio1046.4
sialic acid binding Ig like lectin 1ENSG00000088827SIGLEC1chr20:3686970-3707128:-Tbio99.683
biotinidaseENSG00000169814BTDchr3:15601341-15645822:+Tbio442.394
serpin family A member 4ENSG00000100665SERPINA4chr14:94561091-94569913:+Tbio117.041
peptidylprolyl isomerase like 1ENSG00000137168PPIL1chr6:36854827-36875024:-Tbio59.5861
cysteine rich secretory protein 3ENSG00000096006CRISP3chr6:49727384-49744437:-Tbio46.0318
solute carrier family 17 member 3ENSG00000124564SLC17A3chr6:25833066-25882286:-Tbio12.4328
phospholipid scramblase 4ENSG00000114698PLSCR4chr3:146192339-146251179:-Tbio110.204
transmembrane serine protease 11FENSG00000198092TMPRSS11Fchr4:68053198-68129880:-Tdark0
serine protease 35ENSG00000146250PRSS35chr6:83512538-83525704:+Tdark1.34583
NEDD8 activating enzyme E1 subunit 1ENSG00000159593NAE1chr16:66802875-66873256:-Tchem20.6556
mitogen-activated protein kinase 11ENSG00000185386MAPK11chr22:50263713-50270767:-Tchem91.8954
serine protease 2ENSG00000275896PRSS2chr7:142748662-142774564:+Tchem30.0873
CD37 moleculeENSG00000104894CD37chr19:49335171-49343335:+Tbio63.0886
acid sensing ion channel subunit 3ENSG00000213199ASIC3chr7:151048292-151052756:+Tchem80.3325
autophagy related 4B cysteine peptidaseENSG00000168397ATG4Bchr2:241637213-241673857:+Tbio30.0232
serine protease 57ENSG00000185198PRSS57chr19:685546-695498:-Tbio303.395
solute carrier family 23 member 2ENSG00000089057SLC23A2chr20:4852356-5010293:-Tbio100.49
SH3 domain binding kinase 1ENSG00000188322SBK1chr16:28292519-28323849:+Tchem5.16667

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