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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
Rab geranylgeranyltransferase subunit alpha	ENSG00000100949	RABGGTA	chr14:24265538-24271739:-	Tdark	3.91667
potassium voltage-gated channel subfamily A member 5	ENSG00000130037	KCNA5	chr12:5043989-5046788:+	Tclin	343.658
ribosomal protein S6 kinase B2	ENSG00000175634	RPS6KB2	chr11:67428460-67435408:+	Tbio	101.458
solute carrier family 25 member 19	ENSG00000125454	SLC25A19	chr17:75272981-75289510:-	Tbio	56.2694
solute carrier family 6 member 13	ENSG00000010379	SLC6A13	chr12:220621-262873:-	Tbio	33.171
serpin family B member 13	ENSG00000197641	SERPINB13	chr18:63586989-63604639:+	Tbio	19.7782
potassium voltage-gated channel subfamily C member 3	ENSG00000131398	KCNC3	chr19:50311937-50333515:-	Tclin	40.9585
solute carrier family 16 member 5	ENSG00000170190	SLC16A5	chr17:75087727-75106162:+	Tdark	2.58333
neuroligin 3	ENSG00000196338	NLGN3	chrX:71144831-71171201:+	Tbio	43.9663
PHD finger protein 13	ENSG00000116273	PHF13	chr1:6613685-6624033:+	Tbio	10.5833
mucin 17, cell surface associated	ENSG00000169876	MUC17	chr7:101020072-101058745:+	Tbio	21.2324
lysine demethylase 2B	ENSG00000089094	KDM2B	chr12:121429097-121581015:-	Tchem	22.8244
SET domain and mariner transposase fusion gene	ENSG00000170364	SETMAR	chr3:4303304-4317567:+	Tbio	46.4297
porcupine O-acyltransferase	ENSG00000102312	PORCN	chrX:48508962-48520814:+	Tchem	107.442
natural killer cell triggering receptor	ENSG00000114857	NKTR	chr3:42600614-42648741:+	Tbio	68.8429
paraoxonase 3	ENSG00000105852	PON3	chr7:95359944-95396368:-	Tbio	69.1583
adenylate cyclase 3	ENSG00000138031	ADCY3	chr2:24819169-24919839:-	Tbio	68.9653
transmembrane serine protease 13	ENSG00000137747	TMPRSS13	chr11:117900643-117929459:-	Tbio	34.9095
prolyl 4-hydroxylase subunit alpha 1	ENSG00000122884	P4HA1	chr10:73007217-73096974:-	Tchem	15.6838
cytochrome P450 family 4 subfamily A member 22	ENSG00000162365	CYP4A22	chr1:47137435-47149741:+	Tbio	6.27534

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