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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
phosphoinositide-3-kinase regulatory subunit 5	ENSG00000141506	PIK3R5	chr17:8878911-8965712:-	Tbio	29.1895
phosphodiesterase 3A	ENSG00000172572	PDE3A	chr12:20369245-20684381:+	Tclin	92.4921
calcium voltage-gated channel auxiliary subunit beta 2	ENSG00000165995	CACNB2	chr10:18140677-18541869:+	Tbio	26.1641
solute carrier family 25 member 13	ENSG00000004864	SLC25A13	chr7:96120220-96322147:-	Tbio	207.595
contactin associated protein family member 4	ENSG00000152910	CNTNAP4	chr16:76277278-76559238:+	Tbio	1.60476
R-spondin 2	ENSG00000147655	RSPO2	chr8:107899316-108083648:-	Tbio	15.1138
potassium voltage-gated channel modifier subfamily G member 3	ENSG00000171126	KCNG3	chr2:42442017-42494097:-	Tclin	12.5981
membrane bound O-acyltransferase domain containing 7	ENSG00000125505	MBOAT7	chr19:54173412-54189882:-	Tbio	4.31667
adhesion G protein-coupled receptor L1	ENSG00000072071	ADGRL1	chr19:14147743-14206187:-	Tbio	154.843
carnosine dipeptidase 1	ENSG00000150656	CNDP1	chr18:74534440-74587212:+	Tbio	85.0777
solute carrier family 25 member 3	ENSG00000075415	SLC25A3	chr12:98593591-98606379:+	Tbio	50.7399
proteasome 20S subunit beta 8	ENSG00000204264	PSMB8	chr6:32840717-32844703:-	Tclin	137.678
solute carrier family 36 member 1	ENSG00000123643	SLC36A1	chr5:151437046-151492381:+	Tbio	57.8929
protein phosphatase 3 catalytic subunit alpha	ENSG00000138814	PPP3CA	chr4:101023409-101348278:-	Tchem	60.0379
potassium voltage-gated channel modifier subfamily S member 1	ENSG00000124134	KCNS1	chr20:45092310-45101112:-	Tclin	6.31908
sorbitol dehydrogenase	ENSG00000140263	SORD	chr15:45023104-45077185:+	Tchem	113.75
cyclin dependent kinase like 2	ENSG00000138769	CDKL2	chr4:75578005-75630716:-	Tchem	103.921
bone marrow stromal cell antigen 1	ENSG00000109743	BST1	chr4:15702950-15738313:+	Tbio	72.7449
cholinergic receptor nicotinic beta 2 subunit	ENSG00000160716	CHRNB2	chr1:154567781-154580026:+	Tclin	51.3279
frizzled class receptor 9	ENSG00000188763	FZD9	chr7:73433783-73436120:+	Tbio	26.781

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