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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
tubulin beta 2A class IIa	ENSG00000137267	TUBB2A	chr6:3153669-3157526:-	Tclin	20.9512
parathyroid hormone	ENSG00000152266	PTH	chr11:13492055-13496181:-	Tbio	13052.7
adhesion G protein-coupled receptor F5	ENSG00000069122	ADGRF5	chr6:46852512-46954943:-	Tbio	3.0877
interleukin 13	ENSG00000169194	IL13	chr5:132656263-132661110:+	Tbio	1872.16
ATPase H+/K+ transporting subunit alpha	ENSG00000105675	ATP4A	chr19:35550043-35563658:-	Tclin	382.528
NIMA related kinase 6	ENSG00000119408	NEK6	chr9:124257606-124353307:+	Tchem	36.8131
CDC42 binding protein kinase gamma	ENSG00000171219	CDC42BPG	chr11:64823387-64844569:-	Tbio	2
KH RNA binding domain containing, signal transduction associated 1	ENSG00000121774	KHDRBS1	chr1:32013829-32060850:+	Tbio	237.213
serpin family A member 11	ENSG00000186910	SERPINA11	chr14:94442464-94452790:-	Tdark	0.424242
lysine demethylase 7A	ENSG00000006459	KDM7A	chr7:140084746-140177035:-	Tchem	5.3913
free fatty acid receptor 4	ENSG00000186188	FFAR4	chr10:93566665-93604480:+	Tchem	77.3579
lysosomal associated membrane protein 2	ENSG00000005893	LAMP2	chrX:120427827-120469365:-	Tbio	262.732
flavin containing dimethylaniline monoxygenase 1	ENSG00000010932	FMO1	chr1:171248471-171285978:+	Tbio	52.1929
ependymin related 1	ENSG00000086289	EPDR1	chr7:37683843-37951941:+	Tbio	12.9629
solute carrier family 30 member 4	ENSG00000104154	SLC30A4	chr15:45479611-45522807:-	Tbio	26.052
epithelial mitogen	ENSG00000182585	EPGN	chr4:74308473-74315307:+	Tbio	9.59857
C-C motif chemokine receptor 9	ENSG00000173585	CCR9	chr3:45886504-45903177:+	Tchem	105.708
prostate androgen-regulated mucin-like protein 1	ENSG00000169116	PARM1	chr4:74933095-75050115:+	Tbio	6.86667
3-ketodihydrosphingosine reductase	ENSG00000119537	KDSR	chr18:63327726-63367510:-	Tbio	9.43056
cholinergic receptor nicotinic alpha 7 subunit	ENSG00000175344	CHRNA7	chr15:32030488-32172521:+		0

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