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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
2,4-dienoyl-CoA reductase 1	ENSG00000104325	DECR1	chr8:90001405-90052092:+	Tbio	507.946
signal regulatory protein gamma	ENSG00000089012	SIRPG	chr20:1629152-1657779:-	Tbio	6.60341
chromobox 4	ENSG00000141582	CBX4	chr17:79833156-79839429:-	Tchem	120.237
scavenger receptor cysteine rich family member with 5 domains	ENSG00000179954	SSC5D	chr19:55488404-55519098:+	Tbio	2.30952
iodothyronine deiodinase 1	ENSG00000211452	DIO1	chr1:53891239-53911086:+	Tclin	59.3965
apolipoprotein O	ENSG00000184831	APOO	chrX:23833353-23907934:-	Tbio	11.6698
cell division cycle 14B	ENSG00000081377	CDC14B	chr9:96490241-96619830:-	Tbio	22.8528
receptor activity modifying protein 3	ENSG00000122679	RAMP3	chr7:45157791-45186302:+	Tclin	35.5798
sodium voltage-gated channel alpha subunit 1	ENSG00000144285	SCN1A	chr2:165989160-166128047:-	Tclin	636.769
SPARC like 1	ENSG00000152583	SPARCL1	chr4:87473335-87531061:-	Tbio	39.0569
sodium voltage-gated channel alpha subunit 8	ENSG00000196876	SCN8A	chr12:51590266-51812864:+	Tclin	115.06
ATPase H+ transporting V0 subunit d1	ENSG00000159720	ATP6V0D1	chr16:67438014-67481237:-	Tbio	5.31667
folate receptor beta	ENSG00000165457	FOLR2	chr11:72216601-72221950:+	Tchem	87.4609
uroplakin 3A	ENSG00000100373	UPK3A	chr22:45284982-45295874:+	Tbio	57.0921
fukutin	ENSG00000106692	FKTN	chr9:105558130-105641118:+	Tbio	196.709
H4 clustered histone 3	ENSG00000197061	HIST1H4C	chr6:26103876-26104310:+	Tbio	41.2345
elastin microfibril interfacer 1	ENSG00000138080	EMILIN1	chr2:27078567-27086408:+	Tbio	38.9004
peptidylprolyl isomerase domain and WD repeat containing 1	ENSG00000113593	PPWD1	chr5:65563236-65587549:+	Tbio	2.97619
defensin alpha 5	ENSG00000164816	DEFA5	chr8:7055304-7056734:-	Tbio	125.337
solute carrier organic anion transporter family member 1A2	ENSG00000084453	SLCO1A2	chr12:21264600-21419594:-	Tbio	213.735

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