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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
nidogen 1	ENSG00000116962	NID1	chr1:235975830-236065162:-	Tbio	144.292
calsequestrin 2	ENSG00000118729	CASQ2	chr1:115700007-115768781:-	Tbio	83.5496
aspartylglucosaminidase	ENSG00000038002	AGA	chr4:177430770-177442503:-	Tbio	120.158
podocan like 1	ENSG00000132000	PODNL1	chr19:13931187-13953392:-	Tdark	0
growth differentiation factor 5	ENSG00000125965	GDF5	chr20:35433347-35454746:-	Tbio	263.403
glycogen phosphorylase B	ENSG00000100994	PYGB	chr20:25248069-25298014:+	Tbio	174.691
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	ENSG00000049239	H6PD	chr1:9234775-9271337:+	Tbio	439.345
solute carrier family 38 member 1	ENSG00000111371	SLC38A1	chr12:46183063-46270017:-	Tbio	34.2572
aspartic peptidase retroviral like 1	ENSG00000244617	ASPRV1	chr2:69960089-69962265:-	Tbio	140.257
interleukin 10 receptor subunit alpha	ENSG00000110324	IL10RA	chr11:117986348-118001483:+	Tbio	138.262
serpin family I member 2	ENSG00000114204	SERPINI2	chr3:167441789-167479004:-	Tbio	29.8095
ecto-NOX disulfide-thiol exchanger 1	ENSG00000120658	ENOX1	chr13:43213518-43786908:-	Tbio	24.7245
tribbles pseudokinase 2	ENSG00000071575	TRIB2	chr2:12716889-12742734:+	Tbio	37.4851
cytochrome P450 family 1 subfamily A member 2	ENSG00000140505	CYP1A2	chr15:74748844-74756202:+	Tchem	1808.33
CD47 molecule	ENSG00000196776	CD47	chr3:108043298-108091025:-	Tbio	335.855
nuclear receptor coactivator 1	ENSG00000084676	NCOA1	chr2:24491914-24770702:+	Tchem	172.601
aldehyde dehydrogenase 3 family member A2	ENSG00000072210	ALDH3A2	chr17:19648136-19677598:+	Tbio	96.0639
FMR1 autosomal homolog 2	ENSG00000129245	FXR2	chr17:7591230-7614871:-	Tbio	15.825
lysine demethylase 6A	ENSG00000147050	KDM6A	chrX:44873177-45112602:+	Tbio	101.128
carboxypeptidase A6	ENSG00000165078	CPA6	chr8:67422125-67746345:-	Tbio	298.333

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