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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
adenylate cyclase 2	ENSG00000078295	ADCY2	chr5:7396208-7830081:+	Tbio	130.637
alcohol dehydrogenase 5 (class III), chi polypeptide	ENSG00000197894	ADH5	chr4:99070978-99088801:-	Tchem	213.418
protein tyrosine phosphatase receptor type O	ENSG00000151490	PTPRO	chr12:15322397-15597399:+	Tbio	51.9423
glutamate ionotropic receptor kainate type subunit 1	ENSG00000171189	GRIK1	chr21:29536933-29940033:-	Tclin	144.094
serine protease 16	ENSG00000112812	PRSS16	chr6:27247701-27256624:+	Tbio	11.902
synaptic vesicle glycoprotein 2B	ENSG00000185518	SV2B	chr15:91099950-91301309:+	Tbio	10.2218
SRSF protein kinase 1	ENSG00000096063	SRPK1	chr6:35832966-35921342:-	Tchem	68.332
H4 histone 16	ENSG00000197837	HIST4H4	chr12:14767999-14771131:-		0
CD200 receptor 1	ENSG00000163606	CD200R1	chr3:112921209-112975122:-	Tbio	49.525
tyrosyl-DNA phosphodiesterase 2	ENSG00000111802	TDP2	chr6:24649977-24667033:-	Tchem	47.4238
purinergic receptor P2Y13	ENSG00000181631	P2RY13	chr3:151326312-151329548:-	Tchem	14.7353
CD226 molecule	ENSG00000150637	CD226	chr18:69831158-69961803:-	Tbio	184.217
nuclear receptor subfamily 2 group C member 2	ENSG00000177463	NR2C2	chr3:14947584-15053600:+	Tchem	61.4445
AKT1 substrate 1	ENSG00000204673	AKT1S1	chr19:49869033-49878459:-	Tchem	54.7998
frizzled class receptor 1	ENSG00000157240	FZD1	chr7:91264364-91271326:+	Tbio	33.1563
tudor domain containing 10	ENSG00000163239	TDRD10	chr1:154502219-154548147:+	Tdark	0.375
procollagen C-endopeptidase enhancer 2	ENSG00000163710	PCOLCE2	chr3:142815922-142889203:-	Tbio	6.33333
ubiquitin like modifier activating enzyme 6	ENSG00000033178	UBA6	chr4:67612652-67701179:-	Tchem	10.648
glycophorin A (MNS blood group)	ENSG00000170180	GYPA	chr4:144109303-144140751:-	Tbio	343.946
cyclic nucleotide gated channel subunit alpha 1	ENSG00000198515	CNGA1	chr4:47935977-48016672:-	Tchem	39.3971

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