PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
C-C motif chemokine ligand 8ENSG00000108700CCL8chr17:34319036-34321402:+Tbio99.059
adhesion G protein-coupled receptor D1ENSG00000111452ADGRD1chr12:130953907-131141469:+Tbio6.88886
nuclear receptor subfamily 1 group D member 2ENSG00000174738NR1D2chr3:23945260-23980618:+Tbio96.3697
sodium voltage-gated channel alpha subunit 2ENSG00000136531SCN2Achr2:165239402-165392310:+Tclin284.731
ciliary neurotrophic factor receptorENSG00000122756CNTFRchr9:34551432-34590140:-Tbio46.6954
ephrin B3ENSG00000108947EFNB3chr17:7705202-7711378:+Tbio34.526
kelch like family member 32ENSG00000186231KLHL32chr6:96924620-97140754:+Tdark1
V-set and immunoglobulin domain containing 2ENSG00000019102VSIG2chr11:124747472-124752238:-Tbio140.701
ubiquinol-cytochrome c reductase core protein 2ENSG00000140740UQCRC2chr16:21952660-21983660:+Tbio8.92004
selenoprotein SENSG00000131871VIMPchr15:101270817-101277500:-Tbio75.8015
phosphatidylinositol-4-phosphate 5-kinase type 1 alphaENSG00000143398PIP5K1Achr1:151197949-151249536:+Tbio15.7292
ADAM metallopeptidase with thrombospondin type 1 motif 16ENSG00000145536ADAMTS16chr5:5140330-5320304:+Tbio10.4425
ribosomal protein S6 kinase A4ENSG00000162302RPS6KA4chr11:64359148-64372215:+Tchem9.21652
ceramide kinaseENSG00000100422CERKchr22:46684411-46738261:-Tbio53.9576
BMP binding endothelial regulatorENSG00000164619BMPERchr7:33904911-34155872:+Tbio130.972
receptor interacting serine/threonine kinase 4ENSG00000183421RIPK4chr21:41739369-41767106:-Tchem28.6448
retinal G protein coupled receptorENSG00000148604RGRchr10:84245053-84259960:+Tbio54.8807
glutamate ionotropic receptor AMPA type subunit 3ENSG00000125675GRIA3chrX:123184153-123490915:+Tclin113.937
solute carrier organic anion transporter family member 2B1ENSG00000137491SLCO2B1chr11:75100563-75206549:+Tchem106.048
purinergic receptor P2Y14ENSG00000174944P2RY14chr3:151212117-151278467:-Tbio55.6863

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