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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
cytochrome P450 family 11 subfamily B member 2	ENSG00000179142	CYP11B2	chr8:142910559-142917843:-	Tchem	619.079
fibroblast growth factor binding protein 3	ENSG00000174721	FGFBP3	chr10:91906589-91909483:-	Tbio	2.17424
sphingosine-1-phosphate lyase 1	ENSG00000166224	SGPL1	chr10:70815961-70881173:+	Tchem	1923.99
collagen type XXVIII alpha 1 chain	ENSG00000215018	COL28A1	chr7:7356203-7535853:-	Tdark	2
homeodomain interacting protein kinase 3	ENSG00000110422	HIPK3	chr11:33256672-33357023:+	Tchem	22.0016
solute carrier family 22 member 18	ENSG00000110628	SLC22A18	chr11:2899721-2925246:+	Tbio	32.6775
agouti related neuropeptide	ENSG00000159723	AGRP	chr16:67482571-67483813:-	Tbio	241.743
inhibin subunit beta B	ENSG00000163083	INHBB	chr2:120346143-120351808:+	Tbio	38.2257
N-acetyl-alpha-glucosaminidase	ENSG00000108784	NAGLU	chr17:42536172-42544449:+	Tbio	305.576
ELOVL fatty acid elongase 3	ENSG00000119915	ELOVL3	chr10:102226328-102229589:+	Tchem	3.25754
SP140 nuclear body protein	ENSG00000079263	SP140	chr2:230203110-230313215:+	Tbio	10.9083
solute carrier organic anion transporter family member 4C1	ENSG00000173930	SLCO4C1	chr5:102233986-102296549:-	Tbio	8.52638
C-C motif chemokine ligand 23	ENSG00000274736	CCL23	chr17:36013056-36017968:-	Tbio	44.1059
protein tyrosine phosphatase receptor type F	ENSG00000142949	PTPRF	chr1:43525187-43623666:+	Tchem	162.692
lysine demethylase 5A	ENSG00000073614	KDM5A	chr12:280129-389454:-	Tchem	34.42
ribonucleotide reductase regulatory TP53 inducible subunit M2B	ENSG00000048392	RRM2B	chr8:102204502-102239118:-	Tbio	97.7595
protein kinase cAMP-activated catalytic subunit beta	ENSG00000142875	PRKACB	chr1:84078062-84238498:+	Tchem	13.1959
microtubule associated serine/threonine kinase 1	ENSG00000105613	MAST1	chr19:12833951-12874951:+	Tchem	14.6257
glutathione peroxidase 7	ENSG00000116157	GPX7	chr1:52602372-52609051:+	Tbio	13.4468
adhesion G protein-coupled receptor B2	ENSG00000121753	ADGRB2	chr1:31727117-31764893:-	Tbio	15.1491

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