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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
zinc finger RANBP2-type containing 3	ENSG00000121988	ZRANB3	chr2:135136916-135531236:-	Tbio	91.05
interleukin 1 receptor associated kinase 4	ENSG00000198001	IRAK4	chr12:43758944-43789543:+	Tchem	133.074
solute carrier family 16 member 11	ENSG00000174326	SLC16A11	chr17:7041630-7043923:-	Tbio	6.30952
zinc finger CCCH-type and G-patch domain containing	ENSG00000197114	ZGPAT	chr20:63707465-63736142:+	Tbio	7.18095
hydrogen voltage gated channel 1	ENSG00000122986	HVCN1	chr12:110627841-110704950:-	Tbio	228.483
lysine methyltransferase 2E (inactive)	ENSG00000005483	KMT2E	chr7:105014179-105114361:+	Tbio	31.7972
bromodomain testis associated	ENSG00000137948	BRDT	chr1:91949371-92014426:+	Tchem	31.0591
chromodomain helicase DNA binding protein 3	ENSG00000170004	CHD3	chr17:7884806-7912760:+	Tbio	65.4832
G protein-coupled receptor 158	ENSG00000151025	GPR158	chr10:25175062-25602226:+	Tbio	3.26496
hepsin	ENSG00000105707	HPN	chr19:35040506-35066571:+	Tchem	87.9765
ATPase H+ transporting V1 subunit H	ENSG00000047249	ATP6V1H	chr8:53715557-53843558:-	Tbio	12.25
myeloid derived growth factor	ENSG00000074842	MYDGF	chr19:4641374-4670370:-	Tbio	71.95
IFI30 lysosomal thiol reductase	ENSG00000216490	IFI30	chr19:18173162-18178117:+	Tbio	45.9004
intelectin 2	ENSG00000158764	ITLN2	chr1:160945025-160954799:-	Tbio	36.8778
neurexin 2	ENSG00000110076	NRXN2	chr11:64606174-64723188:-	Tbio	5.74167
protein tyrosine phosphatase receptor type S	ENSG00000105426	PTPRS	chr19:5158495-5340803:-	Tchem	36.4706
solute carrier family 35 member E4	ENSG00000100036	SLC35E4	chr22:30635652-30669016:+	Tdark	0
F-box and leucine rich repeat protein 19	ENSG00000099364	FBXL19	chr16:30923055-30948783:+	Tdark	2.54514
ADAM metallopeptidase with thrombospondin type 1 motif 3	ENSG00000156140	ADAMTS3	chr4:72280969-72568799:-	Tbio	5.46786
endothelin 2	ENSG00000127129	EDN2	chr1:41478775-41484673:-	Tbio	185.653

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