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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
adrenomedullin	ENSG00000148926	ADM	chr11:10304680-10307397:+	Tbio	1077.73
PDZ binding kinase	ENSG00000168078	PBK	chr8:27809620-27838095:-	Tchem	107.747
checkpoint kinase 2	ENSG00000183765	CHEK2	chr22:28687743-28742422:-	Tchem	885.308
apolipoprotein B	ENSG00000084674	APOB	chr2:21001429-21044073:-	Tchem	7552.25
coagulation factor III, tissue factor	ENSG00000117525	F3	chr1:94529225-94541800:-	Tchem	473.56
fms related receptor tyrosine kinase 1	ENSG00000102755	FLT1	chr13:28300344-28495128:-	Tclin	1335.07
WEE1 G2 checkpoint kinase	ENSG00000166483	WEE1	chr11:9573681-9593457:+	Tchem	183.691
LIF receptor subunit alpha	ENSG00000113594	LIFR	chr5:38474963-38608354:-	Tbio	110.164
C-C motif chemokine ligand 20	ENSG00000115009	CCL20	chr2:227813842-227817564:+	Tbio	375.787
cytochrome P450 family 24 subfamily A member 1	ENSG00000019186	CYP24A1	chr20:54153449-54173973:-	Tchem	416.683
kallikrein related peptidase 4	ENSG00000167749	KLK4	chr19:50906352-50910738:-	Tchem	1338.71
eukaryotic translation initiation factor 4A1	ENSG00000161960	EIF4A1	chr17:7572706-7579005:+	Tchem	96.3364
coagulation factor X	ENSG00000126218	F10	chr13:113122814-113149529:+	Tclin	3139.95
CD68 molecule	ENSG00000129226	CD68	chr17:7579467-7582113:+	Tbio	2234.84
pyruvate kinase M1/2	ENSG00000067225	PKM	chr15:72199029-72231822:-	Tchem	447.468
L1 cell adhesion molecule	ENSG00000198910	L1CAM	chrX:153861514-153909223:-	Tbio	867.924
vascular endothelial growth factor C	ENSG00000150630	VEGFC	chr4:176683538-176792727:-	Tbio	780.027
endothelial cell specific molecule 1	ENSG00000164283	ESM1	chr5:54977864-55022671:-	Tbio	111.087
major histocompatibility complex, class I, B	ENSG00000234745	HLA-B	chr6:31353872-31357188:-	Tbio	6027.77
interleukin 11	ENSG00000095752	IL11	chr19:55364389-55370463:-	Tbio	543.983

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