PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
chondroadherin likeENSG00000100399CHADLchr22:41229510-41240934:-Tbio1.25
lactoperoxidaseENSG00000167419LPOchr17:58218548-58268518:+Tbio465.788
arylsulfatase family member IENSG00000183876ARSIchr5:150296343-150339307:-Tbio63.9595
ubiquitin specific peptidase 19ENSG00000172046USP19chr3:49108046-49120938:-Tbio10.5
laminin subunit alpha 4ENSG00000112769LAMA4chr6:112108760-112254939:-Tbio42.7093
fibronectin leucine rich transmembrane protein 1ENSG00000126500FLRT1chr11:64103188-64119173:+Tdark1.41667
alpha kinase 1ENSG00000073331ALPK1chr4:112285509-112442620:+Tbio243.069
cytochrome P450 family 11 subfamily B member 1ENSG00000160882CYP11B1chr8:142872356-142879846:-Tclin312.543
matrix metallopeptidase 25ENSG00000008516MMP25chr16:3046681-3060726:+Tchem48.9435
glutamate metabotropic receptor 1ENSG00000152822GRM1chr6:146027646-146437598:+Tchem94.0627
PMS1 homolog 1, mismatch repair system componentENSG00000064933PMS1chr2:189784085-189877629:+Tbio81.9934
arginine-glutamic acid dipeptide repeatsENSG00000142599REREchr1:8352397-8817643:-Tbio26.9483
bromodomain adjacent to zinc finger domain 2BENSG00000123636BAZ2Bchr2:159318979-159616692:-Tchem5.66667
solute carrier family 52 member 2ENSG00000185803SLC52A2chr8:144354135-144361272:+Tbio17.6667
nicastrinENSG00000162736NCSTNchr1:160343272-160358952:+Tbio114.851
adhesion G protein-coupled receptor G1ENSG00000205336ADGRG1chr16:57610652-57665580:+Tbio68.8969
olfactomedin like 3ENSG00000116774OLFML3chr1:113979391-114035572:+Tdark5.925
nuclear receptor subfamily 6 group A member 1ENSG00000148200NR6A1chr9:124517275-124771310:-Tbio69.9286
solute carrier family 7 member 8ENSG00000092068SLC7A8chr14:23125295-23183674:-Tbio6.37182
glutaminyl-peptide cyclotransferaseENSG00000115828QPCTchr2:37344574-37373322:+Tchem59.2701

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