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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
dual oxidase 1	ENSG00000137857	DUOX1	chr15:45129933-45165576:+	Tbio	52.8822
S100 calcium binding protein A13	ENSG00000189171	S100A13	chr1:153618787-153634092:-	Tbio	30.8746
striated muscle enriched protein kinase	ENSG00000072195	SPEG	chr2:219434846-219498287:+	Tbio	54.8298
myocilin	ENSG00000034971	MYOC	chr1:171635417-171652683:-	Tbio	589.003
carnitine palmitoyltransferase 2	ENSG00000157184	CPT2	chr1:53196429-53214197:+	Tchem	353.346
pyroglutamylated RFamide peptide receptor	ENSG00000186867	QRFPR	chr4:121329312-121381059:-	Tchem	13.7602
hexokinase domain containing 1	ENSG00000156510	HKDC1	chr10:69220303-69267559:+	Tbio	4.63333
membrane bound transcription factor peptidase, site 1	ENSG00000140943	MBTPS1	chr16:84053761-84116906:-	Tchem	124.79
solute carrier family 10 member 2	ENSG00000125255	SLC10A2	chr13:103043998-103066846:-	Tclin	271.021
copper chaperone for superoxide dismutase	ENSG00000173992	CCS	chr11:66592821-66606019:+	Tbio	50.45
5-methyltetrahydrofolate-homocysteine methyltransferase reductase	ENSG00000124275	MTRR	chr5:7851186-7906025:+	Tbio	385.465
protein tyrosine phosphatase receptor type B	ENSG00000127329	PTPRB	chr12:70515866-70637440:-	Tchem	51.6055
endothelin converting enzyme like 1	ENSG00000171551	ECEL1	chr2:232479827-232487828:-	Tbio	39.4528
left-right determination factor 1	ENSG00000243709	LEFTY1	chr1:225886282-225911382:-	Tbio	18.2499
sirtuin 7	ENSG00000187531	SIRT7	chr17:81911939-81921323:-	Tbio	51.2004
tetraspanin 7	ENSG00000156298	TSPAN7	chrX:38561370-38688920:+	Tbio	27.0531
contactin 1	ENSG00000018236	CNTN1	chr12:40692442-41072418:+	Tbio	45.1157
coagulation factor XIII B chain	ENSG00000143278	F13B	chr1:197039191-197067267:-	Tbio	146.475
5-hydroxytryptamine receptor 2C	ENSG00000147246	HTR2C	chrX:114584078-114910061:+	Tclin	514.665
protein tyrosine phosphatase receptor type E	ENSG00000132334	PTPRE	chr10:127907061-128085855:+	Tbio	18.8678

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