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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
interleukin 11 receptor subunit alpha	ENSG00000137070	IL11RA	chr9:34650702-34661892:+	Tclin	36.0687
sirtuin 4	ENSG00000089163	SIRT4	chr12:120302316-120313249:+	Tbio	32.7266
carnosine dipeptidase 2	ENSG00000133313	CNDP2	chr18:74495816-74523454:+	Tbio	230.446
solute carrier family 35 member B2	ENSG00000157593	SLC35B2	chr6:44254096-44257890:-	Tbio	85.0731
chromodomain Y like 2	ENSG00000166446	CDYL2	chr16:80597906-80804329:-	Tbio	1.18333
endonuclease, poly(U) specific	ENSG00000111405	ENDOU	chr12:47709734-47725567:-	Tbio	457.708
MEFV innate immuity regulator, pyrin	ENSG00000103313	MEFV	chr16:3242028-3256627:-	Tbio	1348.88
testis specific serine kinase 6	ENSG00000178093	TSSK6	chr19:19512418-19515685:-	Tbio	3.625
aldehyde dehydrogenase 8 family member A1	ENSG00000118514	ALDH8A1	chr6:134917390-134950122:-	Tbio	2.25758
transient receptor potential cation channel subfamily V member 2	ENSG00000187688	TRPV2	chr17:16415542-16437003:+	Tbio	83.2761
serglycin	ENSG00000122862	SRGN	chr10:69088106-69104811:+	Tbio	281.102
X-C motif chemokine receptor 1	ENSG00000173578	XCR1	chr3:46017024-46027742:-	Tbio	27.8877
ephrin A4	ENSG00000243364	EFNA4	chr1:155063731-155069553:+	Tbio	13.9147
phospholipase A2 group V	ENSG00000127472	PLA2G5	chr1:20028179-20091190:+	Tchem	44.6076
glutamate ionotropic receptor kainate type subunit 4	ENSG00000149403	GRIK4	chr11:120511759-120988904:+	Tclin	74.4304
adenosine deaminase 2	ENSG00000093072	CECR1	chr22:17178790-17221989:-	Tbio	128.265
ubiquitin like with PHD and ring finger domains 2	ENSG00000147854	UHRF2	chr9:6413151-6507054:+	Tbio	33.556
salt inducible kinase 2	ENSG00000170145	SIK2	chr11:111602391-111730853:+	Tchem	17.7988
cytochrome P450 family 7 subfamily B member 1	ENSG00000172817	CYP7B1	chr8:64587763-64798761:-	Tbio	65.7428
cyclin dependent kinase 20	ENSG00000156345	CDK20	chr9:87966441-87974753:-	Tbio	352.282

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