PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
B and T lymphocyte associatedENSG00000186265BTLAchr3:112463968-112499561:-Tbio66.2983
caspase 5ENSG00000137757CASP5chr11:104994235-105023168:-Tchem13.904
palmitoyl-protein thioesterase 1ENSG00000131238PPT1chr1:40072705-40097703:-Tbio351.707
cartilage intermediate layer proteinENSG00000138615CILPchr15:65194758-65211488:-Tbio33.6813
solute carrier family 4 member 5ENSG00000188687SLC4A5chr2:74216242-74343414:-Tbio29.4119
betaine--homocysteine S-methyltransferase 2ENSG00000132840BHMT2chr5:79069717-79089466:+Tchem8.4343
amine oxidase copper containing 1ENSG00000002726AOC1chr7:150824627-150861504:+Tchem1164.29
apelin receptorENSG00000134817APLNRchr11:57233577-57237314:-Tchem136.65
beta-1,4-galactosyltransferase 1ENSG00000086062B4GALT1chr9:33104082-33167356:-Tbio182.69
FER tyrosine kinaseENSG00000151422FERchr5:108747822-109196841:+Tchem40.7528
immunoglobulin lambda like polypeptide 5ENSG00000254709IGLL5chr22:22734620-22896107:+Tbio0
mitogen-activated protein kinase 13ENSG00000156711MAPK13chr6:36127809-36144524:+Tchem33.3571
solute carrier family 12 member 8ENSG00000221955SLC12A8chr3:125082636-125212864:-Tbio7.76786
ATP binding cassette subfamily B member 9ENSG00000150967ABCB9chr12:122920951-122981649:-Tbio30.2774
cardiotrophin like cytokine factor 1ENSG00000175505CLCF1chr11:67364168-67374177:-Tbio26.9472
fibrinogen like 2ENSG00000127951FGL2chr7:77193371-77199826:-Tbio45.7385
prolyl 3-hydroxylase 3ENSG00000110811P3H3chr12:6828410-6839851:+Tbio32.4778
rhodopsinENSG00000163914RHOchr3:129528640-129535169:+Tbio3878.86
serine protease 23ENSG00000150687PRSS23chr11:86791059-86952910:+Tdark2.99801
cytochrome P450 family 4 subfamily F member 11ENSG00000171903CYP4F11chr19:15912367-15934867:-Tbio7.53886

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