PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
homeodomain interacting protein kinase 1ENSG00000163349HIPK1chr1:113929192-113977869:+Tbio11.1817
ribonuclease H1ENSG00000171865RNASEH1chr2:3544793-3558616:-Tchem69.5333
SNF2 histone linker PHD RING helicaseENSG00000146414SHPRHchr6:145864245-145964423:-Tbio6.20281
ATPase H+ transporting V0 subunit bENSG00000117410ATP6V0Bchr1:43974487-43978295:+Tbio5.16667
RNA polymerase I and III subunit CENSG00000171453POLR1Cchr6:43509702-43529585:+Tbio18.2167
thioredoxin related transmembrane protein 2ENSG00000213593TMX2chr11:57712600-57740973:+Tdark5.69683
G protein-coupled receptor 135ENSG00000181619GPR135chr14:59429022-59465342:-Tbio0.734126
interleukin 36 receptor antagonistENSG00000136695IL36RNchr2:113058638-113065382:+Tbio62.8073
fibroblast growth factor 18ENSG00000156427FGF18chr5:171419656-171457623:+Tbio49.232
sphingosine kinase 2ENSG00000063176SPHK2chr19:48619291-48630717:+Tchem145.597
neuropeptide Y receptor Y1ENSG00000164128NPY1Rchr4:163323961-163344832:-Tchem28.1175
adhesion G protein-coupled receptor E5ENSG00000123146ADGRE5chr19:14380501-14408725:+Tbio67.0437
proteasome 20S subunit beta 7ENSG00000136930PSMB7chr9:124353466-124415444:-Tbio3.85098
solute carrier family 7 member 6ENSG00000103064SLC7A6chr16:68264516-68301823:+Tbio10.6123
insulin like growth factor binding protein like 1ENSG00000137142IGFBPL1chr9:38408994-38424447:-Tbio3.2
vascular endothelial growth factor BENSG00000173511VEGFBchr11:64234538-64238793:+Tclin115.727
solute carrier family 22 member 15ENSG00000163393SLC22A15chr1:115976498-116070054:+Tdark1
integral membrane protein 2BENSG00000136156ITM2Bchr13:48233158-48270357:+Tbio111.486
chordin like 1ENSG00000101938CHRDL1chrX:110673856-110795819:-Tbio89.0801
dickkopf like acrosomal protein 1ENSG00000104901DKKL1chr19:49361783-49375116:+Tbio29.8363

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