PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
heat shock protein family A (Hsp70) member 1BENSG00000204388HSPA1Bchr6:31827735-31830255:+Tchem112.803
Fc fragment of IgG receptor and transporterENSG00000104870FCGRTchr19:49506816-49526333:+Tchem1135.54
solute carrier organic anion transporter family member 5A1ENSG00000137571SLCO5A1chr8:69667047-69835064:-Tdark4.85
collagen type XXIV alpha 1 chainENSG00000171502COL24A1chr1:85729233-86156943:-Tdark0.111111
inosine monophosphate dehydrogenase 1ENSG00000106348IMPDH1chr7:128392277-128410252:-Tclin89.1239
tudor domain containing 12ENSG00000173809TDRD12chr19:32719753-32829580:+Tdark0.342857
interleukin 36 gammaENSG00000136688IL36Gchr2:112973203-112985665:+Tbio9.29057
complement C1sENSG00000182326C1Schr12:6988259-7071032:+Tchem483.749
thymic stromal lymphopoietinENSG00000145777TSLPchr5:111070062-111078024:+Tbio308.789
apolipoprotein B mRNA editing enzyme catalytic subunit 3AENSG00000128383APOBEC3Achr22:38952741-38992778:+Tbio63.7563
calsyntenin 1ENSG00000171603CLSTN1chr1:9729026-9824526:-Tbio12.5499
laminin subunit beta 1ENSG00000091136LAMB1chr7:107923799-108003255:-Tbio69.3485
matrix metallopeptidase 24ENSG00000125966MMP24chr20:35226654-35277000:+Tbio17.156
dorsal inhibitory axon guidance proteinENSG00000162490DRAXINchr1:11691729-11725857:+Tbio4.40476
STE20 like kinaseENSG00000065613SLKchr10:103967201-104029233:+Tchem58.2802
peptide YYENSG00000131096PYYchr17:43952738-44004469:-Tbio777.733
sirtuin 5ENSG00000124523SIRT5chr6:13574529-13615158:+Tbio53.0889
microfibril associated protein 5ENSG00000197614MFAP5chr12:8637346-8662888:-Tbio43.8782
proteasome 20S subunit alpha 2ENSG00000106588PSMA2chr7:42916857-42932223:-Tbio13.4012
carbohydrate sulfotransferase 1ENSG00000175264CHST1chr11:45648877-45665622:-Tbio12.302

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