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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
collagen type XII alpha 1 chain	ENSG00000111799	COL12A1	chr6:75084326-75206051:-	Tbio	28.2558
neuropilin and tolloid like 2	ENSG00000171208	NETO2	chr16:47077703-47143997:-	Tbio	10.3206
potassium voltage-gated channel subfamily A member 2	ENSG00000177301	KCNA2	chr1:110593580-110631474:-	Tclin	203.282
cytochrome P450 family 2 subfamily R member 1	ENSG00000186104	CYP2R1	chr11:14877440-14892252:-	Tbio	75.4605
quiescin sulfhydryl oxidase 1	ENSG00000116260	QSOX1	chr1:180154834-180204030:+	Tbio	47.2456
hydroxysteroid 17-beta dehydrogenase 6	ENSG00000025423	HSD17B6	chr12:56752161-56787790:+	Tbio	313.487
heterogeneous nuclear ribonucleoprotein A1	ENSG00000135486	HNRNPA1	chr12:54280193-54287088:+	Tchem	266.095
ficolin 1	ENSG00000085265	FCN1	chr9:134905890-134917963:-	Tbio	73.9671
ATP binding cassette subfamily A member 4	ENSG00000198691	ABCA4	chr1:93992835-94121132:-	Tbio	495.069
O-sialoglycoprotein endopeptidase	ENSG00000092094	OSGEP	chr14:20446411-20455105:-	Tbio	16.6333
neurocan	ENSG00000130287	NCAN	chr19:19211973-19252233:+	Tbio	25.9377
solute carrier family 26 member 7	ENSG00000147606	SLC26A7	chr8:91209494-91398152:+	Tbio	9.9671
phosphodiesterase 6B	ENSG00000133256	PDE6B	chr4:625584-670782:+	Tclin	145.939
F2R like thrombin or trypsin receptor 3	ENSG00000127533	F2RL3	chr19:16888860-16892606:+	Tchem	103.133
fibronectin leucine rich transmembrane protein 2	ENSG00000185070	FLRT2	chr14:85530144-85654426:+	Tbio	5.92998
thrombospondin 3	ENSG00000169231	THBS3	chr1:155195588-155209051:-	Tbio	17.1896
cadherin EGF LAG seven-pass G-type receptor 3	ENSG00000008300	CELSR3	chr3:48636469-48662915:-	Tbio	6.92473
adenosine A2b receptor	ENSG00000170425	ADORA2B	chr17:15944917-15975746:+	Tclin	52.5848
laminin subunit beta 2	ENSG00000172037	LAMB2	chr3:49121114-49133118:-	Tbio	48.6036
polo like kinase 3	ENSG00000173846	PLK3	chr1:44800225-44805990:+	Tchem	115.111

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